Skip to main content

Loperamide

ADVERTISEMENT
Identification
Molecular formula
C29H33ClN2O
CAS number
53179-11-6
IUPAC name
3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one
State
State

At room temperature, loperamide is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
735.20
Boiling point (Kelvin)
1 008.35
General information
Molecular weight
477.03g/mol
Molar mass
477.0340g/mol
Density
1.1908g/cm3
Appearence

Loperamide is typically found as a white or off-white crystalline powder.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one

The solubility of 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one can be influenced by several factors, including its chemical structure and the solvent used. This compound is characterized by a complex organic framework which tends to exhibit the following solubility traits:

  • Non-polarity: The presence of multiple aromatic rings suggests a degree of non-polar character, which may lead to limited solubility in polar solvents such as water.
  • Higher solubility in organic solvents: It is likely to be more soluble in organic solvents like ethanol, dimethyl sulfoxide (DMSO), or methanol, where non-polar and moderately polar interactions prevail.
  • Temperature dependence: As with many organic compounds, its solubility may increase with temperature, making it more soluble in hot solvents.

When considering the solubility characteristics of this compound, it is essential to note that experimental determination is the most reliable approach. Solubility can vary significantly based on specific conditions, including:

  1. The nature of the solvent used.
  2. The temperature and pressure conditions.
  3. Potential interactions with other solutes in the solution.

In summary, while theoretical predictions can suggest its solubility behavior, empirical data should always be sought for precise determination. Thus, as with many complex compounds, understanding solubility demands both theoretical insight and practical experimentation.

Interesting facts

Interesting Facts About 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one

3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one is a compound that has garnered attention in the field of medicinal chemistry due to its potential therapeutic applications. Here are some engaging points about this intriguing compound:

  • Multi-faceted Structure: The compound features a complex structure that includes a chlorophenyl group, a phenyl group, and a piperazinyl moiety. This diverse arrangement of functional groups contributes to its unique properties and interactions within biological systems.
  • Pharmacological Potential: Compounds with piperazine moieties are often investigated for their ability to interact with neurotransmitter receptors, suggesting that this compound might exhibit psychoactive properties or could serve as a lead compound for drug development.
  • Research Interest: Due to its unique structural attributes and potential bioactivity, this compound has gained interest in research programs focusing on mental health disorders and neurological diseases.
  • Chlorinated Compounds: The presence of the chlorine atom in the structure may enhance lipophilicity, potentially affecting how the compound penetrates the blood-brain barrier, a crucial consideration in drug design.
  • Modern Synthesis: Advanced synthetic methods can yield this compound with impressive precision. The combination of organic synthesis techniques and modern analytical methods is essential in understanding and developing such compounds.
  • In Silico Studies: Computational chemistry approaches, such as molecular docking studies, are increasingly employed to predict how this compound might interact with specific biological targets, paving the way for future in vivo experiments.

In summary, 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one exemplifies the intricate world of chemical compounds with potential applications in various fields, particularly within pharmacology. As research progresses, it will be exciting to observe how this compound may contribute to advancements in therapeutic strategies.

Synonyms
23902-89-8
beta-(p-Chlorophenyl)phenethyl 4-phenethylpiperazinyl ketone
1-(3-(p-Chlorophenyl)-3-phenylpropionyl)-4-phenethylpiperazine
KETONE, beta-(p-CHLOROPHENYL)PHENETHYL 4-PHENETHYLPIPERAZINYL
Piperazine, 1-(3-(p-chlorophenyl)-3-phenylpropionyl)-4-phenethyl-
RefChem:350452
3-(4-chlorophenyl)-3-phenyl-1-[4-(2-phenylethyl)piperazin-1-yl]propan-1-one
DTXSID80946699