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Desmethyltrazodone

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Identification
Molecular formula
C23H22ClN3O
CAS number
76296-93-6
IUPAC name
3-(4-chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)piperazin-1-yl]propan-1-one
State
State

At room temperature, it is found in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.00
Boiling point (Celsius)
480.00
Boiling point (Kelvin)
753.00
General information
Molecular weight
419.90g/mol
Molar mass
419.9400g/mol
Density
1.2000g/cm3
Appearence

This compound typically appears as a white to off-white crystalline powder. It may vary slightly in shade depending on purity and specific crystalline form.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)piperazin-1-yl]propan-1-one

The solubility of the compound 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)piperazin-1-yl]propan-1-one is a crucial aspect to consider for its practical applications and behavior in various environments. Being a complex organic compound, its solubility can be influenced by several factors:

  • Polarity: The presence of functional groups such as -Cl (chlorine) and -N (nitrogen from the piperazine and pyridine moieties) contributes to the overall polarity of the molecule. This may enhance solubility in polar solvents.
  • Solvent Choice: It is essential to test the solubility in various solvents. Typically, compounds of this nature show improved solubility in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol, rather than in water.
  • Temperature: Solubility often increases with temperature, thus elevated temperatures may facilitate the dissolution of this compound in certain solvents.
  • Concentration: Higher concentrations of the compound may lead to precipitation, indicating that its solubility has reached a limit in the chosen solvent.

Understanding the solubility of this compound is not merely a technical consideration; it plays a vital role in pharmacokinetics and formulation in medicinal chemistry. As the saying goes, "Like dissolves like," meaning that the solubility will significantly depend on the nature of the solvent. Therefore, evaluating its solubility can provide insights into its reactivity, bioavailability, and overall performance in chemical applications.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)piperazin-1-yl]propan-1-one

The compound 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)piperazin-1-yl]propan-1-one represents a fascinating integration of organic chemistry, pharmacology, and molecular design. It showcases several interesting aspects:

  • Diverse Functionality: This compound features a complex structure that includes a piperazine ring, which is known for its versatility in medicinal chemistry. The presence of a 4-chlorophenyl moiety adds to its potential biological activity, enhancing its lipophilicity and ability to interact with various molecular targets.
  • Medicinal Potential: Compounds with similar structures have been investigated for their potential therapeutic effects, particularly in treating neurological disorders, due to their interactions with neurotransmitter systems. The incorporation of a pyridine ring may influence binding affinities to receptor sites, making it a subject of interest in drug development.
  • Synthetic Pathways: The synthesis of such compounds usually involves multi-step organic reactions, which can teach valuable lessons in synthetic strategies, reaction mechanisms, and the importance of each functional group in contributing to overall reactivity and stability.
  • Research Implications: Due to its unique structure, this compound could be explored for the development of new ligands that target specific receptors in cellular pathways. Understanding how variations in its structure influence activity can lead to advancements in personalized medicine.

As a testament to the ongoing evolution of medicinal chemistry, 3-(4-chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)piperazin-1-yl]propan-1-one serves as an exciting example for scientists and students alike, illustrating the delicate balance of chemistry required to develop promising therapeutic agents. In the words of chemists, "Every molecule tells a story," and compounds like this are pivotal chapters in the ongoing narrative of drug discovery.

Synonyms
23904-74-7
beta-(p-Chlorophenyl)phenethyl 4-(2-pyridyl)piperazinyl ketone
1-(3-(p-Chlorophenyl)-3-phenylpropionyl)-4-(2-pyridyl)piperazine
KETONE, beta-(p-CHLOROPHENYL)PHENETHYL 4-(2-PYRIDYL)PIPERAZINYL
Piperazine, 1-(3-(p-chlorophenyl)-3-phenylpropionyl)-4-(2-pyridyl)-
RefChem:350443
3-(4-chlorophenyl)-3-phenyl-1-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one
DTXSID70946704
3-(p-Chlorophenyl)-3-phenyl-1-[4-(2-pyridyl)-1-piperazinyl]-1-propanone
3-(4-chlorophenyl)-3-phenyl-1-[4-(pyridin-2-yl)piperazin-1-yl]propan-1-one