Skip to main content

Lorpiprazole

ADVERTISEMENT
Identification
Molecular formula
C26H27ClN2O
CAS number
61136-56-7
IUPAC name
3-(4-chlorophenyl)-3-phenyl-1-[4-(p-tolyl)piperazin-1-yl]propan-1-one
State
State

At room temperature, Lorpiprazole is typically in a solid state.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
445.01g/mol
Molar mass
445.0090g/mol
Density
1.2000g/cm3
Appearence

Lorpiprazole appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-3-phenyl-1-[4-(p-tolyl)piperazin-1-yl]propan-1-one

The compound 3-(4-chlorophenyl)-3-phenyl-1-[4-(p-tolyl)piperazin-1-yl]propan-1-one presents some interesting considerations regarding its solubility.

Factors Influencing Solubility:

  • Polarity: The presence of multiple aromatic rings and a piperazine moiety suggests a potentially moderate polarity, influencing its solubility profile in various solvents.
  • Hydrogen Bonding: The piperazine group may engage in hydrogen bonding, which could enhance solubility in polar solvents.
  • Solvent Interaction: Depending on the solvent, interactions such as dipole-dipole forces and van der Waals forces will predominantly dictate the solubility behavior.

For example, this compound is likely to have greater solubility in organic solvents such as ethanol or DMSO, while exhibiting reduced solubility in water due to its hydrophobic components from the aromatic structures. Hence, the solubility can be summarized as:

  • High in: Ethanol, DMSO
  • Moderate in: Methanol
  • Low in: Water

To quote a related observation, “The balance between hydrophilic and hydrophobic elements within a compound fundamentally influences its solubility across different solvents.” Such insights highlight the importance of molecular structure in predicting solubility characteristics.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)-3-phenyl-1-[4-(p-tolyl)piperazin-1-yl]propan-1-one

This compound, often referred to in scientific circles by its structural characteristics, belongs to a class of molecules known for their pharmacological potential. Here are some key points that highlight its significance:

  • Pharmacological Applications: Compounds like 3-(4-chlorophenyl)-3-phenyl-1-[4-(p-tolyl)piperazin-1-yl]propan-1-one are often investigated for their possible applications in treating various disorders, including mood disorders and anxiety.
  • Structural Features: The presence of the chlorophenyl and piperazine rings signifies this compound's complexity and ability to interact with multiple biological pathways.
  • Mechanism of Action: Compounds in this category commonly function as *receptor modulators*, influencing neurotransmitter systems in the brain, which can lead to therapeutic effects.
  • Synthesis: The synthetic pathways for creating such compounds can involve multi-step reactions, often requiring advanced techniques in organic chemistry and careful manipulation of functional groups.
  • Research Interests: Due to its intricate structure, researchers are keen to explore the *structure-activity relationships* (SAR), understanding how changes in its composition affect its biological activity.

Furthermore, as a compound with potential therapeutic applications, it represents a fascinating intersection of chemistry and medicine, showcasing how molecular design can lead to advancements in pharmacotherapy. Its unique characteristics serve as an inspiration for ongoing research in drug discovery and development.

Synonyms
23904-72-5
beta-(p-Chlorophenyl)phenethyl 4-(p-tolyl)piperazinyl ketone
1-(3-(p-Chlorophenyl)-3-phenylpropionyl)-4-(p-tolyl)piperazine
KETONE, beta-(p-CHLOROPHENYL)PHENETHYL 4-(p-TOLYL)PIPERAZINYL
Piperazine, 1-(3-(p-chlorophenyl)-3-phenylpropionyl)-4-(p-tolyl)-
RefChem:350451
3-(4-chlorophenyl)-1-[4-(4-methylphenyl)piperazin-1-yl]-3-phenylpropan-1-one
DTXSID10946703
3-(p-Chlorophenyl)-3-phenyl-1-[4-(p-tolyl)-1-piperazinyl]-1-propanone