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Clonidine Hydrochloride

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Identification
Molecular formula
C9H11Cl2N2O
CAS number
4205-90-7
IUPAC name
3-(4-chlorophenyl)-5-(2-piperidin-1-ium-1-ylethyl)isoxazole;chloride
State
State

In its pure form, clonidine hydrochloride is a solid at room temperature. As a solid, it is stable and amenable to handling under standard laboratory conditions.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
331.60
Boiling point (Kelvin)
604.75
General information
Molecular weight
266.12g/mol
Molar mass
266.1200g/mol
Density
1.3783g/cm3
Appearence

Clonidine Hydrochloride generally appears as an off-white, crystalline powder. It is soluble in water, making it useful for preparing aqueous solutions for therapeutic administration. Its texture is typical of many crystalline substances, being slightly gritty when examined closely.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-5-(2-piperidin-1-ium-1-ylethyl)isoxazole;chloride

The solubility of the compound 3-(4-chlorophenyl)-5-(2-piperidin-1-ium-1-ylethyl)isoxazole; chloride can be influenced by multiple factors including its ionic character and structural properties.

Key Factors Affecting Solubility:

  • Ionic Nature: The presence of the chloride ion suggests that this compound is likely soluble in polar solvents, particularly water, as ionic compounds tend to dissolve well in polar environments.
  • Hydrophilicity: The piperidine moiety enhances the hydrophilic characteristic, thus promoting solubility in aqueous solutions.
  • Hydrophobic Interactions: However, the 4-chlorophenyl group may introduce hydrophobic characteristics, which could limit solubility in nonpolar solvents.

As a general observation:

  • Solubility in water: Likely high due to the ionic nature of the chloride and the presence of nitrogen-containing piperidine.
  • Solubility in organic solvents: Potentially lower; care must be taken when choosing solvents for formulation purposes.

Overall, the solubility of this compound reflects a balance between its polar and nonpolar components, emphasizing an interesting solubility profile that should be further investigated in practical applications.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)-5-(2-piperidin-1-ium-1-ylethyl)isoxazole;chloride

This compound is a fascinating example of a multifunctional chemical with properties that could be relevant in various fields, especially in pharmaceuticals and material science. Its unique structure consists of an isoxazole ring bonded with a piperidine moiety, presenting distinct modes of action and interactions.

Key Features:

  • Molecular Architecture: The presence of a chlorophenyl group greatly enhances its potential as a pharmacophore, contributing to its activity by increasing lipophilicity.
  • Ionization: Being a piperidinium derivative implies that it can exist in a charged form, which is crucial for interactions with biological targets, such as receptors or enzymes.
  • Biological Implications: Compounds structured like this may have implications in drug design, particularly in neuroactive agents, where piperidine derivatives are known for their neurotransmitter modulating activities.

In the realm of chemistry, the isoxazole ring is of significant interest due to its ability to act as an electron-withdrawing group, fostering unique reactivity patterns that are vital for synthetic applications. As a class, isoxazoles are frequently explored for their potential roles as anti-inflammatory, antimicrobial, and anticancer agents.


Moreover, the integration of the piperidine structure allows researchers to investigate:

  • Structure-Activity Relationships: The modification of substituents can lead to profound changes in bioactivity.
  • Pharmacokinetics: Understanding how this compound behaves in biological systems offers insights into its therapeutic efficacy and safety profile.

As emphasized by researchers, "The exploration of complex molecules like 3-(4-chlorophenyl)-5-(2-piperidin-1-ium-1-ylethyl)isoxazole;chloride opens new frontiers in drug discovery." Future studies could reveal more about its specific biological roles and applications, enhancing our understanding of such intricate compounds.

Synonyms
3-(p-Chlorophenyl)-5-(2-piperidinoethyl)isoxazole hydrochloride
5243-94-7
ISOXAZOLE, 3-(p-CHLOROPHENYL)-5-(2-PIPERIDINOETHYL)-, HYDROCHLORIDE