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3-(4-chlorophenyl)azetidine

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Identification
Molecular formula
C9H10ClN
CAS number
156726-27-1
IUPAC name
3-(4-chlorophenyl)azetidine
State
State

At room temperature, 3-(4-Chlorophenyl)azetidine is generally a liquid, indicating its low melting point and suggesting relative volatility given its moderate boiling point.

Melting point (Celsius)
18.00
Melting point (Kelvin)
291.15
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.15
General information
Molecular weight
169.63g/mol
Molar mass
169.6340g/mol
Density
1.1445g/cm3
Appearence

3-(4-Chlorophenyl)azetidine is typically a colorless to pale yellow liquid, although it may sometimes appear as a crystalline solid. The compound may have a faint chemical odor which is characteristic of many organochlorine compounds.

Comment on solubility

Solubility of 3-(4-chlorophenyl)azetidine

3-(4-chlorophenyl)azetidine, a compound characterized by its azetidine ring and chlorobenzene substituent, presents unique solubility properties. Understanding its solubility behavior is crucial in various applications, including drug formulation and organic synthesis.

The solubility of this compound in different solvents can be influenced by several factors:

  • Polarity: The presence of the 4-chlorophenyl group typically enhances the compound's polarity, which may increase its solubility in polar solvents.
  • Hydrogen Bonding: The azetidine can potentially form hydrogen bonds with solvents, which can also contribute to its solubility profile.
  • Temperature: As with many organic compounds, higher temperatures may increase solubility in specific solvent systems.

In practical terms, it is often observed that:

  • 3-(4-chlorophenyl)azetidine is more soluble in polar protic solvents such as methanol or ethanol.
  • It exhibits limited solubility in non-polar solvents like hexane due to reduced interaction between the molecule and the solvent.

As a final note, experimental approaches such as solubility tests should be employed to determine the precise solubility characteristics, which may vary significantly based on conditions and solvent choice. Understanding these dynamics is essential for harnessing the full potential of this compound in various scientific fields.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)azetidine

3-(4-chlorophenyl)azetidine is a fascinating compound with intriguing properties and applications in the field of medicinal chemistry.

Key Characteristics

  • Azetidine Ring Structure: The compound contains a four-membered azetidine ring, which is known for its rigid structure and unique reactivity. This small cyclic amine has been studied for its potential to enhance the biological activity of various pharmaceuticals.
  • Chlorophenyl Group: The presence of the 4-chlorophenyl substituent significantly influences the compound's interactions with biological targets. Halogenated phenyl groups are often associated with improved potency in drug design.

Potential Applications

This compound exhibits potential in several fields, including:

  • Pharmaceutical Development: Due to its structural features, 3-(4-chlorophenyl)azetidine is of interest in the development of new therapeutics, especially in the treatment of neurological disorders.
  • Research Tool: It can also serve as a valuable tool in studying receptor interactions and signaling pathways due to its ability to modify biological activity.

Molecular Interactions

The azetidine ring can participate in various interactions that are essential during drug-receptor binding. The rigidity of the ring, combined with the electronic effects of the 4-chlorophenyl group, allows this compound to fit into biological targets in a manner that can modulate their function significantly.

Conclusion

Overall, 3-(4-chlorophenyl)azetidine represents a promising compound that bridges the gap between synthetic chemistry and pharmacology. Its unique structure opens avenues for further research, aiming to develop new therapeutic agents with enhanced efficacy and selectivity.

Synonyms
7215-02-3
3-(p-Chlorophenyl)azetidine
L 2406
AZETIDINE, 3-(p-CHLOROPHENYL)-
BRN 1424809
DTXSID90222471
DTXCID90144962
5-20-06-00286 (beilstein handbook reference)
3-(4-chlorophenyl)azetidine
MFCD01665297
SCHEMBL6779675
UPXXQMBUBSHBEZ-UHFFFAOYSA-N
GS0562
AKOS017398274
AT15505
SB52077
SDCCGSBI-0662966.P001
SY267181
WS-01134
DB-098899
EN300-247045