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Chlorphenesin

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Identification
Molecular formula
C16H18ClNO
CAS number
104-29-0
IUPAC name
3-[(4-chlorophenyl)methylamino]-1-phenyl-propan-1-ol
State
State

Chlorphenesin is typically a solid at room temperature, presenting itself as a crystalline powder.

Melting point (Celsius)
77.00
Melting point (Kelvin)
350.15
Boiling point (Celsius)
338.80
Boiling point (Kelvin)
611.95
General information
Molecular weight
246.78g/mol
Molar mass
246.7270g/mol
Density
1.2900g/cm3
Appearence

Chlorphenesin typically appears as a white to off-white crystalline powder. It is often odorless or may have a very faint characteristic smell. The compound is usually very pure with a homogeneous texture.

Comment on solubility

Solubility of 3-[(4-chlorophenyl)methylamino]-1-phenyl-propan-1-ol

The solubility of 3-[(4-chlorophenyl)methylamino]-1-phenyl-propan-1-ol can be understood by considering various factors that influence the dissolution of organic compounds in solvents.

Factors Influencing Solubility

  • Polarity: This compound contains both polar and non-polar functional groups, leading to a unique solubility profile in different solvents.
  • Molecular Weight: The relatively high molecular weight can affect solubility; larger molecules often exhibit lower solubility in water.
  • Hydrogen Bonding: The presence of hydroxyl (-OH) groups facilitates hydrogen bonding with solvent molecules, enhancing solubility in polar solvents.
  • Hydrophobic Interactions: The aromatic rings contribute to hydrophobic character, potentially limiting solubility in polar solvents.

For practical applications, this compound may exhibit moderate solubility in water and higher solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), making it crucial to carefully select solvents based on the intended use. As one researcher aptly stated, "The choice of solvent is as important as the compound itself." Ultimately, understanding these nuances of solubility can enhance the effectiveness of this compound in various chemical reactions and processes.

Interesting facts

Interesting Facts about 3-[(4-chlorophenyl)methylamino]-1-phenyl-propan-1-ol

This compound, often referred to in research contexts as a potential pharmaceutical agent, possesses intriguing features that highlight its significance in medicinal chemistry. Here are some key aspects:

  • Pharmacological Interest: The compound exhibits potential as an antidepressant due to its ability to interact with neurotransmitter systems in the brain, notably serotonin.
  • Chlorine Substitution: The presence of the 4-chlorophenyl group enhances the molecule's lipophilicity, which can improve its pharmacokinetic properties.
  • Synthesis Routes: It is often synthesized through multistep processes involving amine and alcohol functionalities, making it a fascinating subject in synthetic organic chemistry.
  • Activity Studies: Various studies have investigated its activity against other central nervous system disorders, revealing its potential beyond just antidepressant properties.
  • Importance in Research: As a scaffold in drug development, its structure provides a platform for the exploration of new therapeutic agents, making it a valuable compound for medicinal chemists.

Moreover, understanding the interactions of this compound at the molecular level can provide insights into designing more effective treatments with reduced side effects. As one researcher noted, "The intricate balance between structure and activity in compounds like this one is what drives innovation in medicinal chemistry." This highlights the vital role of compounds like 3-[(4-chlorophenyl)methylamino]-1-phenyl-propan-1-ol in the ongoing pursuit of new therapeutic solutions.