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Amiodarone hydrochloride

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Identification
Molecular formula
C25H29ClI2N2O3 · HCl
CAS number
19774-82-4
IUPAC name
3-(4-chlorophenyl)propyl-[(3,4-dimethoxyphenyl)methyl]-ethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate
State
State

Amiodarone hydrochloride is usually provided in a solid crystalline form at room temperature and is often used in medicinal applications in the form of tablets or an injectable solution.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
289.00
Boiling point (Kelvin)
562.15
General information
Molecular weight
681.79g/mol
Molar mass
681.7860g/mol
Density
1.4902g/cm3
Appearence

Amiodarone hydrochloride is typically a white to slightly yellow crystalline powder. It is known for its relative stability under standard conditions and its crystalline nature reflects its purity and potency.

Comment on solubility

Solubility of 3-(4-chlorophenyl)propyl-[(3,4-dimethoxyphenyl)methyl]-ethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate

The solubility of the chemical compound 3-(4-chlorophenyl)propyl-[(3,4-dimethoxyphenyl)methyl]-ethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate can often be influenced by several factors, including its structure and polarity. This compound, featuring both an ammonium group and a hydrophobic phenyl structure, presents a complex solubility profile:

  • Ammonium Group: The presence of the ammonium moiety is likely to enhance solubility in polar solvents such as water, due to its ionic nature.
  • Phenyl Rings: The bulky, hydrophobic phenyl structures may reduce solubility in purely aqueous environments but could interact favorably with organic solvents.
  • Dimethoxy Substituents: The methoxy groups may also contribute to both solubility and the compound's overall polarity, potentially assisting in solvation.

In summary, while one can predict an increased solubility in polar solvents due to the ammonium cation, the phenomenon is complicated by hydrophobic interactions from the phenyl rings. Hence, it’s crucial to evaluate solubility in a series of solvents:

  1. Water
  2. Ethanol
  3. Dichloromethane
  4. Acetonitrile

Due to these factors, a comprehensive understanding of solubility can only be achieved through experimental methods, and as always, "solubility is fundamentally a function of the compound's specific interactions with the solvent."

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)propyl-[(3,4-dimethoxyphenyl)methyl]-ethyl-ammonium; 4-hydroxy-4-oxo-but-2-enoate

This complex compound incorporates a fascinating blend of functional groups and moieties, making it a subject of interest in medicinal chemistry and pharmacology. As a quaternary ammonium compound, it possesses unique properties that can be exploited in various applications, particularly in drug design and synthesis. Here are some key highlights:

  • Diverse Applications: The compound's structure suggests potential activity in areas such as anti-cancer, anti-inflammatory, and antimicrobial research. The presence of halogen and methoxy groups may enhance its biological activity.
  • Structure-Activity Relationship (SAR): Understanding the relationship between its multi-ring structure and pharmacological effects can lead to the development of more effective derivatives. This is vital in fields like drug development, where slight modifications can lead to substantial differences in efficacy.
  • Mechanistic Insights: The quaternary ammonium group enhances solubility in biological systems, which may improve bioavailability and targeted delivery within cells or tissues.
  • Innovative Synthesis: The synthesis of such complex compounds often involves advanced techniques, including multi-step organic synthesis, allowing chemists to explore novel reaction pathways and reactivity of various functional groups.
  • Future Research: Ongoing studies are likely to reveal more about its pharmacokinetics and pharmacodynamics, paving the way for new therapeutic agents that could address current health challenges.

In summary, the intriguing structure of 3-(4-chlorophenyl)propyl-[(3,4-dimethoxyphenyl)methyl]-ethyl-ammonium; 4-hydroxy-4-oxo-but-2-enoate positions it as an important subject in the realm of chemical research, offering numerous gateways into enhanced drug development and therapeutic applications.