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Identification
Molecular formula
C12H10F2N2O3
CAS number
123456-78-9
IUPAC name
3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one
State
State

At room temperature, the compound is a solid, more specifically a crystalline powder. It should be handled with care, avoiding exposure to air and moisture to prevent degradation.

Melting point (Celsius)
152.50
Melting point (Kelvin)
425.65
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
284.24g/mol
Molar mass
284.2410g/mol
Density
1.3562g/cm3
Appearence

The compound appears as an off-white to pale yellow crystalline powder. It is typically synthesized for research purposes and may not be encountered outside of a controlled setting.

Comment on solubility

Solubility of 3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one

The solubility of the compound 3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one (C12H10F2N2O3) can be influenced by several factors, including its molecular structure and the presence of functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of difluoromethoxy and methoxy groups contributes to the compound's polarity, affecting its solubility in polar solvents.
  • Solvent Compatibility: This compound may exhibit improved solubility in polar organic solvents such as methanol and ethanol, while displaying limited solubility in non-polar solvents like hexane.
  • Hydrogen Bonding: The functionality of methoxy groups can engage in hydrogen bonding, enhancing solubility in polar environments.
  • Temperature and Concentration: Solubility is generally temperature-dependent; increasing temperature can enhance the dissolving capacity of this compound.

As a rule of thumb, "like dissolves like," meaning that compounds tend to be more soluble in solvents with similar polarity. Thus, understanding the balance of functional groups within 3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one is crucial for predicting its solubility behavior in various solvent systems.

Interesting facts

Interesting Facts about 3-[4-(Difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one

This fascinating compound, known for its unique structure and potential applications, belongs to the family of pyridazinones, which have garnered much interest in medicinal chemistry. The presence of fluorine atoms in its structure introduces intriguing properties, leading to discussions about its activity in various biological contexts.

Key Features:

  • Fluorinated Compounds: The incorporation of fluorine is known to enhance the metabolic stability of organic molecules. This is particularly valuable in drug design, where prolonged activity can be crucial for therapeutic effects.
  • Biological Activity: Compounds like this pyridazinone are often explored for their potential as inhibitors or modulators in various biochemical pathways, highlighting their utility in pharmaceuticals.
  • Structural Complexity: The combination of a pyridazinone ring with various functional groups, such as methoxy and difluoromethoxy moieties, adds to the compound's complexity, potentially giving rise to interesting interaction dynamics in biological systems.

"The beauty of synthetic chemistry lies in the design of molecules that can perform desired functions." This statement resonates well with the exploration of compounds like this one, as they represent the intersection of innovation and functionality.

Applications and Research Directions:

Ongoing research might explore:

  • The synthesis pathways of this compound and its analogs.
  • Potential applications in drug discovery, especially targeting specific receptors or enzymes.
  • Collaboration with computational chemistry to predict properties and biological interactions.

In summary, 3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one stands out as a remarkable compound, embodying the potential for innovative solutions in the field of chemistry and pharmacology.

Synonyms
zardaverine
101975-10-4
Zardaverina
Zardaverinum
Zardaverine [INN]
6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone
Zardaverinum [INN-Latin]
Zardaverina [INN-Spanish]
6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE
TQ358GWH6Y
DTXSID8042559
CHEBI:46548
6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone
6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one
CHEMBL313842
DTXCID6022559
NCGC00016106-04
3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one
6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one
3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]-
CAS-101975-10-4
3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- [CAS]
Zardaverinum (INN-Latin)
Zardaverina (INN-Spanish)
6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
SMR000449313
SR-01000076204
UNII-TQ358GWH6Y
Zaradaverine
1mkd
1xor
MFCD00867059
6-(4-difluoromethoxy-3-methoxyphenyl)-3(2H)pyridazinone
Tocris-1046
Prestwick0_000977
Prestwick1_000977
Prestwick2_000977
Prestwick3_000977
Lopac-Z-3003
UPCMLD-DP159
Lopac0_001260
SCHEMBL13334
BSPBio_001013
BSPBio_001346
KBioGR_000066
KBioSS_000066
MLS000758207
MLS001401422
SPBio_002924
BPBio1_001115
SCHEMBL14810549
UPCMLD-DP159:001
UPCMLD-DP159:002
BDBM14769
KBio2_000066
KBio2_002634
KBio2_005202
KBio3_000131
KBio3_000132
Bio2_000066
Bio2_000546
HMS1361D08
HMS1571C15
HMS1791D08
HMS1989D08
HMS2051O09
HMS2090L06
HMS2098C15
HMS2235H08
HMS3267C08
HMS3370L18
HMS3393O09
HMS3402D08
HMS3412C09
HMS3676C09
HMS3715C15
BCP06509
Tox21_110307
EX-A11924
AKOS024456348
Tox21_110307_1
Zardaverine phosphodiesterase inhibitor
CCG-100782
CCG-205334
DB02918
NC00032
Zardaverine, phosphodiesterase inhibitor
IDI1_033816
NCGC00016106-01
NCGC00016106-02
NCGC00016106-03
NCGC00016106-05
NCGC00016106-06
NCGC00016106-07
NCGC00016106-08
NCGC00016106-09
NCGC00016106-10
NCGC00016106-11
NCGC00016106-13
NCGC00024963-01
NCGC00024963-02
NCGC00024963-03
NCGC00024963-04
NCGC00024963-05
BZ161227
HY-15485
MS-23783
SBI-0051227.P002
AB00513983
EU-0101260
NS00070483
E98661
Z 3003
AB00513983-03
SR-01000076204-1
SR-01000076204-3
SR-01000076204-5
BRD-K37561857-001-04-9
BRD-K37561857-001-06-4
BRD-K37561857-001-13-0
BRD-K37561857-001-15-5
BRD-K37561857-001-17-1
Q15634082
6-(4-difluoromethoxy-3-methoxy-phenyl)-3[2h]-pyridazinone
6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydropyridazin-3-one
3- [4- (Difluoromethoxy) - 3- methoxyphenyl] - 1H- pyridazin- 6- one
6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one