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Letrozole

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Identification
Molecular formula
C17H11N5
CAS number
112809-51-5
IUPAC name
3-(4-hydroxy-2-methyl-phenyl)-2-methyl-quinazolin-4-one
State
State

At room temperature, letrozole is in a solid state as a crystalline powder.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
619.20
Boiling point (Kelvin)
892.35
General information
Molecular weight
258.27g/mol
Molar mass
258.2670g/mol
Density
1.2700g/cm3
Appearence

Letrozole appears as a white to off-white crystalline powder. It is usually odorless and stable under normal conditions of use and storage.

Comment on solubility

Solubility of 3-(4-hydroxy-2-methyl-phenyl)-2-methyl-quinazolin-4-one

The solubility of 3-(4-hydroxy-2-methyl-phenyl)-2-methyl-quinazolin-4-one is an intriguing aspect of its chemical behavior. This compound exhibits a certain level of solubility, influenced by various factors, which can be outlined as follows:

  • Polarity: The presence of the hydroxyl group (-OH) enhances polarity, making it more soluble in polar solvents such as water.
  • Solvent Interaction: It tends to dissolve better in organic solvents like ethanol or acetone compared to less polar solvents.
  • Temperature Dependency: As with many organic compounds, solubility may increase with temperature, allowing for more efficient dissolution in various applications.
  • pH Influence: The solubility in aqueous solutions can also be pH-dependent, particularly due to the ionizable hydroxyl group.

To summarize, while it is not highly soluble in water, the compound demonstrates a significant solubility in polar organic solvents. Understanding the solubility profiles can aid in the formulation of pharmaceuticals or other applications where the compound’s bioavailability is of concern. As one user noted, "Solubility can make or break the effectiveness of a compound in real-world applications."

Interesting facts

Interesting Facts about 3-(4-hydroxy-2-methyl-phenyl)-2-methyl-quinazolin-4-one

3-(4-hydroxy-2-methyl-phenyl)-2-methyl-quinazolin-4-one, a compound known for its intriguing structure and potential applications in various fields, is part of the quinazoline family, which has been the subject of extensive research due to its diverse pharmacological activities. Here are some captivating facts about this compound:

  • Versatile Applications: Compounds like this one are often investigated for their roles as pharmaceuticals, particularly in anti-cancer and anti-inflammatory research.
  • Unique Structure: The presence of a quinazolinone skeleton along with a hydroxyl group may interact with biological targets, contributing to its potential therapeutic efficacy.
  • Synthetic Routes: The synthesis of this compound involves creative steps that showcase the beauty of organic chemistry, often employing techniques such as cyclization and functional group transformations.
  • Biological Activity: Compounds within the quinazoline class have demonstrated a variety of biological activities, including antimalarial, antiviral, and even antibacterial properties, making them invaluable in medicinal chemistry.
  • Complex Interactions: Research into this compound may reveal interactions at the molecular level with enzymes and receptors—a key to understanding its mechanism of action.

As a scientist or chemistry student, exploring 3-(4-hydroxy-2-methyl-phenyl)-2-methyl-quinazolin-4-one opens a window into the world of drug design and development, provoking thoughts about how subtle changes in structure can significantly impact biological function. Embrace the journey of discovery!

Synonyms
4'-Hydroxymethaqualone
BRN 0888803
3-(4-Hydroxy-2-methylphenyl)-2-methyl-4(3H)-quinazolinone
4(3H)-Quinazolinone, 3-(4-hydroxy-2-methylphenyl)-2-methyl-
DTXSID80198651
5-24-03-00149 (Beilstein Handbook Reference)
DTXCID40121142
4(3H)-Quinazolinone, 3-(4-hydroxy-2-methylphenyl)-2-methyl-(9CI)
hiyzkxxsrnpsqj-uhfffaoysa-n
5060-52-6
4(3H)-QUINAZOLINONE, 3-(4-HYDROXY-o-TOLYL)-2-METHYL-
2-Methyl-3-(4-hydroxy-2-methylphenyl)-3,4-dihydroquinazolin-4-one
SCHEMBL11445400
4(3H)-Quinazolinone, 3-(4-hydroxy-2-methylphenyl)-2-methyl- (9CI)
NS00115911