3-(4-Hydroxyphenyl)-1-phenyl-isothiourea

Identification

Molecular formula

C₁₃H₁₂N₂OS

CAS number

8480-00-0

IUPAC name

3-(4-hydroxyphenyl)-1-phenyl-isothiourea

State

At room temperature, 3-(4-Hydroxyphenyl)-1-phenyl-isothiourea exists in a solid state.

Melting point (Celsius)

218.00

Melting point (Kelvin)

491.15

Boiling point (Celsius)

345.00

Boiling point (Kelvin)

618.15

General information

Molecular weight

242.31g/mol

Molar mass

242.3000g/mol

Density

1.3500g/cm³

Appearence

3-(4-Hydroxyphenyl)-1-phenyl-isothiourea appears as a cream-colored solid. It is used often in chemical synthesis and research.

Comment on solubility

Solubility of 3-(4-hydroxyphenyl)-1-phenyl-isothiourea

3-(4-hydroxyphenyl)-1-phenyl-isothiourea, with its unique structure, exhibits notable solubility properties that are influenced by various factors:

Polarity: The presence of hydroxyl (-OH) groups enhances the compound's ability to interact with polar solvents, particularly water. This gives the compound moderate solubility in polar environments.
Hydrogen Bonding: The hydroxyl group can form hydrogen bonds with water molecules, which facilitates solvation and enhances solubility.
Solubility in Organic Solvents: In addition to water, this compound is generally soluble in organic solvents such as methanol and ethanol, due to its hydrophobic phenyl groups.
Temperature Dependence: Like many organic compounds, the solubility of 3-(4-hydroxyphenyl)-1-phenyl-isothiourea is likely to increase with temperature, making it more soluble in warmer solvents.

In conclusion, while 3-(4-hydroxyphenyl)-1-phenyl-isothiourea exhibits moderate solubility in polar solvents like water due to its hydroxyl groups and hydrogen bonding capabilities, it also demonstrates solubility in organic solvents, showcasing its versatile solubility characteristics.

Interesting facts

Interesting Facts about 3-(4-hydroxyphenyl)-1-phenyl-isothiourea

3-(4-hydroxyphenyl)-1-phenyl-isothiourea, an intriguing compound in the realm of organic chemistry, possesses unique properties that make it a subject of interest among scientists and researchers. Here are some fascinating insights:

Versatile Applications: This compound has been investigated for its potential in various fields, including agrochemicals, pharmaceuticals, and biocides due to its ability to interact with biological systems.
Mechanism of Action: 3-(4-hydroxyphenyl)-1-phenyl-isothiourea may inhibit specific enzymes, which can lead to important implications in understanding the modulation of biological pathways. For example, its potential use in cancer research highlights its role in targeting malignant cells.
Structural Features: The presence of both hydroxy and isothiourea functional groups offers significant insights into the compound’s reactivity and interaction with other chemicals. This dual functionality can enhance its ability to participate in various chemical reactions.
Research Significance: Investigations into this compound have led to discoveries that contribute to our understanding of synthetic pathways and molecular interactions, emphasizing the importance of structure-activity relationships in drug design.
Synthetic Pathways: The synthesis of this compound often involves well-established organic reactions, and its study helps solidify techniques in organic synthesis, including the utilization of isothiocyanate chemistry.

In summary, the study of 3-(4-hydroxyphenyl)-1-phenyl-isothiourea is not only pivotal for its potential applications but also for the profound insights it offers into organic synthesis and biological interactions. As research continues, the full breadth of its capabilities will likely unfold, benefiting both scientific understanding and real-world applications.