Skip to main content

Combretastatin A-4

ADVERTISEMENT
Identification
Molecular formula
C23H23NO3
CAS number
117048-59-6
IUPAC name
3-(4-methoxyphenyl)-2-phenyl-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one
State
State

At room temperature, combretastatin A-4 is a solid. It should be handled with care under inert atmosphere conditions to prevent any possible degradation or reaction.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
388.90
Boiling point (Kelvin)
662.05
General information
Molecular weight
388.47g/mol
Molar mass
388.4680g/mol
Density
1.2300g/cm3
Appearence

Combretastatin A-4 is typically a white to off-white crystalline solid. It may appear in various forms, including powder and crystals, depending on the method of preparation and the degree of purity. The compound is sensitive to air and light, necessitating storage in a dark, sealed container to prevent degradation.

Comment on solubility

Solubility of 3-(4-methoxyphenyl)-2-phenyl-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one

The solubility profile of the compound 3-(4-methoxyphenyl)-2-phenyl-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one is quite intriguing. Here are some key points to consider:

  • Solvent Compatibility: This compound is likely to exhibit varying solubility in different solvents. Generally, it tends to be more soluble in organic solvents like ethanol, methanol, and DMSO, while being poorly soluble in polar protic solvents.
  • Temperature Dependence: Solubility may increase with temperature; hence, higher temperatures could enhance dissolution in various organic solvents.
  • Hydrophilicity vs. Hydrophobicity: The presence of the hydrophobic aromatic rings and the pyrrolidine group points toward a significant hydrophobic character, which often translates to decreased solubility in water.
  • pH Sensitivity: Changes in pH may influence solubility, especially if the compound contains ionizable functional groups. However, detailed experimental data would be necessary to determine this factor.

In general, while the solubility of this compound is expected to be limited in aqueous environments, its solubility in organic solvents makes it suitable for various applications in the laboratory and industry. Further solubility studies could provide more insights into its behavior in different conditions.

Interesting facts

Interesting Facts about 3-(4-methoxyphenyl)-2-phenyl-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one

This compound, known for its complex structure and potential applications, is of considerable interest in both medicinal chemistry and organic synthesis. Here are some captivating aspects:

  • Diverse Applications: Compounds like this one can serve as building blocks for pharmaceutical development, possibly influencing drug discovery processes.
  • Unique Structure: The presence of multiple phenyl rings and functional groups allows for intriguing interactions with biological targets, which can lead to novel therapeutic approaches.
  • Pyrrolidine Component: The incorporation of the pyrrolidine moiety may enhance the compound's bioactivity and binding affinity, making it a subject of interest in research focused on neurological conditions.
  • Potential for Anticancer Activity: Many compounds featuring unsaturated ketones have been explored for anticancer properties. Researchers are continuously investigating similar structures for their ability to inhibit cancer cell growth.

As a student or scientist, it's fascinating to consider how the modifications of a single molecule can lead to vast differences in efficacy and application. As you study compounds like this, you can almost hear the echoes of famous chemists like Linus Pauling who said, “The best way to have a good idea is to have a lot of ideas.” Thus, embracing creativity and innovative thinking is essential in the world of chemical research!

Ultimately, the exploration of compounds with such intricate configurations not only enriches our understanding of organic chemistry but also paves the way for groundbreaking discoveries in the field of medicine.