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3-(4-methoxyphenyl)isothiourea

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Identification
Molecular formula
C8H10N2OS
CAS number
4043-06-1
IUPAC name
3-(4-methoxyphenyl)isothiourea
State
State

At room temperature, 3-(4-methoxyphenyl)isothiourea is in a solid state. It maintains structural integrity and solidity under typical ambient conditions.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
317.00
Boiling point (Kelvin)
590.15
General information
Molecular weight
181.24g/mol
Molar mass
181.2410g/mol
Density
1.2900g/cm3
Appearence

3-(4-Methoxyphenyl)isothiourea appears as a white to off-white crystalline solid. Its fine crystals reflect light, giving it a powdery appearance.

Comment on solubility

Solubility of 3-(4-methoxyphenyl)isothiourea

The solubility of 3-(4-methoxyphenyl)isothiourea in various solvents can vary significantly depending on several factors. This compound, being a substituted isothiourea, exhibits intriguing solubility properties that are worth exploring:

  • Polar Solvents: 3-(4-methoxyphenyl)isothiourea generally shows good solubility in polar protic solvents like water and alcohols, due to its potential to engage in hydrogen bonding.
  • Non-Polar Solvents: In contrast, this compound tends to have reduced solubility in non-polar solvents such as hexane or benzene, which can limit its interactions with the solvent molecules.
  • Temperature Dependence: Solubility can highly depend on temperature; often, increased temperatures enhance solubility for solid compounds like this one.
  • pH Influence: The pH of the solvent system can also play a crucial role, as ionization states of isothiourea can be affected by protonation or deprotonation processes.

It is often observed that compounds with functional groups such as methoxy can increase solubility by allowing for additional interactions. As noted in literature, compounds like 3-(4-methoxyphenyl)isothiourea can exhibit moderate to high solubility in selected solvents, which opens avenues for various applications in synthesis and pharmaceuticals.

In conclusion, understanding the solubility characteristics of 3-(4-methoxyphenyl)isothiourea helps in optimizing its usage in both research and practical applications.

Interesting facts

Interesting Facts about 3-(4-methoxyphenyl)isothiourea

3-(4-methoxyphenyl)isothiourea, often abbreviated as MITU, is a fascinating compound that falls within the category of isothioureas. This class of compounds is notable for their diverse biological activities and potential applications in various fields. Here are some intriguing aspects of MITU:

  • Biological Significance: MITU has been studied for its potential as an antitumor agent. Research suggests that it may inhibit certain cancer cell growth, making it a topic of interest in cancer therapeutics.
  • Structure-Activity Relationship: The molecular structure of MITU allows it to engage in crucial interactions with biological targets. The methoxy group on the aromatic ring enhances its solubility and bioavailability.
  • Reactivity: Isothioureas like MITU typically exhibit remarkable reactivity due to the presence of sulfur in their structure, allowing them to participate in a variety of chemical reactions, including alkylation and acylation processes.
  • Mechanism of Action: Studies have indicated that isothioureas may function through the induction of apoptosis in cancer cells, presenting a promising area for further research in medicinal chemistry.
  • Versatile Applications: Beyond its potential antitumor properties, compounds in this class can be employed in synthesizing other chemical entities, making them valuable in organic synthesis and pharmaceuticals.

This compound showcases the intersection of chemistry and biology, emphasizing the importance of molecular design in developing therapeutic agents. As research progresses, 3-(4-methoxyphenyl)isothiourea may lead to breakthroughs in cancer treatment and other applications.