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3-[(4-Methyl-1-piperidyl)methyl]-1H-indole

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Identification
Molecular formula
C16H20N2
CAS number
123619-33-6
IUPAC name
3-[(4-methyl-1-piperidyl)methyl]-1H-indole
State
State

At room temperature, this compound is typically found in a solid state. Its physical state allows for handling in laboratory settings where solid forms are necessary for reactions and analysis.

Melting point (Celsius)
60.50
Melting point (Kelvin)
333.65
Boiling point (Celsius)
409.60
Boiling point (Kelvin)
682.75
General information
Molecular weight
240.33g/mol
Molar mass
240.3330g/mol
Density
1.1000g/cm3
Appearence

The compound 3-[(4-Methyl-1-piperidyl)methyl]-1H-indole appears as a solid at room temperature. It is typically characterized by its crystalline structure, which may range from white to off-white in color.

Comment on solubility

Solubility of 3-[(4-methyl-1-piperidyl)methyl]-1H-indole

The solubility of the compound 3-[(4-methyl-1-piperidyl)methyl]-1H-indole can be influenced by various factors, including its molecular structure and the solvent used. Here are some key points to consider:

  • Polarity: Due to the presence of both hydrophobic (indole structure) and hydrophilic (piperidyl group) components, this compound exhibits a balance that affects its solubility in water and organic solvents.
  • Water Solubility: Generally, indole derivatives like this compound may have limited solubility in water. However, the presence of the piperidyl moiety can enhance *aqueous solubility* to some extent.
  • Solvent Compatibility: The compound is more likely to be soluble in organic solvents such as ethanol, methanol, and DMSO due to its relatively nonpolar characteristics.
  • Temperature Effects: Increasing temperature often improves the solubility of organic compounds; hence, heating the solvent may assist in dissolving this compound more effectively.

In summary, while the solubility of 3-[(4-methyl-1-piperidyl)methyl]-1H-indole may not be extensive in aqueous environments, it exhibits better solubility profiles in organic solvents and under elevated temperatures. As always, the specific solubility can vary based on experimental conditions and solvent choices.

Interesting facts

Interesting Facts about 3-[(4-methyl-1-piperidyl)methyl]-1H-indole

The compound 3-[(4-methyl-1-piperidyl)methyl]-1H-indole is an intriguing molecule that belongs to a class of compounds known for their diverse biological activities. Here are some key highlights:

  • Structural Importance: This compound features an indole ring, which is characteristic of many natural products and important in various biological processes. Indoles often serve as a backbone in pharmaceuticals due to their broad range of activity.
  • Pharmacological Relevance: The presence of the piperidine moiety is notable as it enhances the compound's potential activity. Piperidine derivatives are known to exhibit a range of biological effects, including analgesic and anti-inflammatory properties.
  • Research Applications: Scientists explore this compound in the context of drug development. Studies suggest its potential in treating neurological disorders, owing to its structural resemblance to other potent neuroactive agents.
  • Synthesis Pathways: The synthesis of this compound involves several organic chemistry techniques, including amine alkylation and cyclization reactions, showcasing the creativity required in modern organic synthetic methods.
  • Multifunctionality: The versatility of the structural components allows for derivatization; modifications can lead to compounds with enhanced efficacy or reduced side effects in therapeutic applications.

In summary, 3-[(4-methyl-1-piperidyl)methyl]-1H-indole stands out as a fascinating compound, bridging chemistry and biology. Its complex structure and potential therapeutic applications make it a significant subject for ongoing research and discovery in the field of medicinal chemistry.

Synonyms
21000-95-3
3-[(4-methylpiperidin-1-yl)methyl]-1H-indole
3-((4-Methylpiperidin-1-yl)methyl)-1H-indole
INDOLE, 3-((4-METHYLPIPERIDINO)METHYL)-
CHEMBL57478
DTXSID30175210
BRN 0191400
AURORA 16336
3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole
3-((4-Methylpiperidino)methyl)indole
RefChem:1087305
Oprea1_382776
Oprea1_731728
DTXCID9097701
SCHEMBL13504100
3-[(4-methylpiperidyl)methyl]indole
BDBM50050469
STK617550
AKOS002266584
PD180937
3-[(4-Methylpiperidino)methyl]-1H-indole
CS-0256852
ST50190326
3-[(4-methyl-1-piperidyl)methyl]-1H-indole
3-[(4-methyl-1-piperidinyl)methyl]-1H-indole
AB00084678-01
EN300-6541568
Z131833926