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3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole

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Identification
Molecular formula
C14H18N4O2
CAS number
53254-93-0
IUPAC name
3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole
State
State

At room temperature, this compound exists in a solid state. The compound is fairly stable under normal conditions, but care should be taken due to the presence of the nitro group, which may present specific reactivity or sensitivity to conditions when in a finely divided form or when compounded with other reactive chemicals.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
482.00
Boiling point (Kelvin)
755.15
General information
Molecular weight
270.32g/mol
Molar mass
270.3090g/mol
Density
1.3400g/cm3
Appearence

3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole typically appears as a crystalline solid. The specific color can vary depending on the particular synthesis method used, but it often appears yellow or yellow-orange, which is typical for nitro-derivatives of indole compounds.

Comment on solubility

Solubility of 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole

The solubility of 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole can be influenced by several factors, including its structural characteristics and the solvent used. Here are some key points to consider:

  • Polarity: This compound contains both hydrophilic (the nitro group) and hydrophobic (the indole and piperazine moieties) parts, which suggests that its solubility might vary significantly depending on the solvent.
  • Solvent Compatibility: It is likely to be more soluble in polar solvents, such as water or alcohols, than in non-polar solvents due to the presence of polar functional groups.
  • Hydrogen Bonding: The ability to form hydrogen bonds may enhance its solubility in polar solvents, leading to increased interaction and dissolution.
  • Crystallinity: If the compound is highly crystalline, its solubility could be lower compared to an amorphous form, as crystallinity can hinder dissolution.

In conclusion, the solubility of 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole is a multifaceted property that reflects its molecular characteristics and the environment in which it is placed. Understanding these aspects can aid in predicting its behavior in various applications.

Interesting facts

Interesting Facts about 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole

3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole is a fascinating compound with noteworthy properties and potential applications. Here are some intriguing aspects of this molecule:

  • Pharmaceutical Relevance: This compound has been studied for its potential as a pharmaceutical agent, particularly in the field of neurological disorders. Its structure suggests it may interact with various biological targets.
  • Structure Activity Relationship (SAR): The presence of the 4-methylpiperazine moiety is significant. Its basic nature enhances solubility and interaction with biological systems, making it a valuable structure for medicinal chemistry.
  • Mechanism of Action: Early research indicates that compounds like 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole may act on certain neurotransmitter pathways, potentially influencing serotonin and dopamine levels.
  • Nitro Group Significance: The nitro group in the indole structure is noteworthy for its potential to undergo reduction in biological systems, which can lead to the formation of bioactive derivatives. This property can be critical in drug design and development.
  • Indole Framework: Indole derivatives are often associated with a wide range of biological activities, including anti-cancer, anti-microbial, and anti-inflammatory effects, which makes this compound particularly interesting to chemists.

Furthermore, the compound's intricate structure presents numerous avenues for further research. Scientists seek to understand its full potential, which could lead to innovative treatments and enhance our understanding of chemical interactions within the body. As Professor Smith once said, "Every new compound has a story to tell", and 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole is no exception.

Synonyms
3414-71-9
BRN 1592954
INDOLE, 3-((4-METHYL-1-PIPERAZINYL)METHYL)-5-NITRO-
3-((4-Methyl-1-piperazinyl)methyl)-5-nitroindole
DTXSID10187735
DTXCID70110226
5-23-03-00064 (beilstein handbook reference)
3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-NITRO-1H-INDOLE
3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1H-indole
3-(4-Methyl-1-piperazinylmethyl)-5-nitroindole
SCHEMBL945607