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LY-293284

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Identification
Molecular formula
C14H18N2
CAS number
2213-58-5
IUPAC name
3-(4-piperidylmethyl)-1H-indole
State
State

At room temperature, 3-(4-piperidylmethyl)-1H-indole is commonly found in a solid state. It may be stored under airtight conditions to prevent moisture absorption.

Melting point (Celsius)
69.50
Melting point (Kelvin)
342.65
Boiling point (Celsius)
394.70
Boiling point (Kelvin)
667.85
General information
Molecular weight
238.31g/mol
Molar mass
238.3200g/mol
Density
1.1500g/cm3
Appearence

3-(4-Piperidylmethyl)-1H-indole is typically a crystalline solid. It may appear as a white to off-white powder. The exact appearance can vary depending on the grade and purity of the sample.

Comment on solubility

Solubility of 3-(4-piperidylmethyl)-1H-indole

The solubility of 3-(4-piperidylmethyl)-1H-indole can be influenced by several factors including its molecular structure and the solvent being used. When considering its solubility, here are some key points to remember:

  • Polarity: The solubility in water tends to be lower due to the indole structure, which is generally more hydrophobic.
  • Organic solvents: This compound is likely to exhibit better solubility in organic solvents like ethanol, methanol, or DMSO because of its nonpolar regions.
  • Temperature: Increasing temperature can enhance solubility for many organic compounds, making it an important variable to consider.
  • pH effects: The solubility may also be affected by the pH of the solution, particularly due to the presence of the piperidine ring, which can impact its ionization state.

In summary, while 3-(4-piperidylmethyl)-1H-indole may not be highly soluble in water, it can dissolve effectively in various organic solvents. This information is critical for applications in pharmaceutical formulations where solubility plays a vital role in bioavailability.

Interesting facts

Interesting Facts about 3-(4-piperidylmethyl)-1H-indole

The compound 3-(4-piperidylmethyl)-1H-indole is a fascinating molecule with various scientific implications. Here are some interesting insights:

  • Structure and Functionality: This compound contains both an indole ring and a piperidine moiety, which contribute to its unique chemical properties. Indoles are often found in naturally occurring compounds, playing significant roles in biological systems.
  • Biological Relevance: Indole derivatives, such as this compound, have been studied for their potential in medicinal chemistry. They exhibit a range of biological activities, including antitumor, antibacterial, and antifungal properties.
  • Affinity for Receptors: The piperidylmethyl group is known to enhance interaction with various receptors, making compounds like 3-(4-piperidylmethyl)-1H-indole potential candidates for drug development targeting neurotransmitter systems.
  • Applications in research: Due to its structural characteristics, this compound is often used in the study of neuropharmacology and the development of new therapies for neurological disorders.
  • Mechanistic Studies: Research involving 3-(4-piperidylmethyl)-1H-indole can deepen the understanding of how certain molecular structures influence biological activity, ultimately guiding drug design strategies.

As a molecule that bridges the fields of organic chemistry and pharmacology, 3-(4-piperidylmethyl)-1H-indole continues to inspire scientists. Its complex structure and potential applications promise exciting developments in medicinal research. Unveiling the mysteries of such compounds holds the key to innovative therapeutic solutions.

Synonyms
3-(piperidin-4-ylmethyl)-1H-indole
3515-49-9
4-(3-Indolylmethyl)piperidine
3-(4-Piperidylmethyl)-1H-indole
3-(4-Piperidinylmethyl)-1H-indole
3-[(piperidin-4-yl)methyl]-1H-indole
CHEMBL429771
1H-Indole, 3-(4-piperidinylmethyl)-
LM 5015
3-(4-Piperidinomethyl) indole
BRN 0176648
4-(3-Indolyl-methyl)-piperidin [German]
4-(3-Indolyl-methyl)-piperidin
MFCD01718591
INDOLE, 3-(4-PIPERIDYLMETHYL)-
1H-Indole, 3-(4-piperidinylmethyl)- (9CI)
SCHEMBL1998835
4-(3-indolyl-methyl)-piperidine
DTXSID50188645
HKYWCJOLDLYIOL-UHFFFAOYSA-N
3-Piperidin-4-ylmethyl-1H-indole
BDBM50029157
AKOS022189214
AS-60509
DB-393853
CS-0186721
C74809
EN300-1838347