3-(4-pyridylmethyleneamino)isothiourea

Identification

Molecular formula

C₈H₁₀N₄S

CAS number

23030-29-1

IUPAC name

3-(4-pyridylmethyleneamino)isothiourea

State

At room temperature, 3-(4-pyridylmethyleneamino)isothiourea is typically found in a solid state. It is important to maintain standard room conditions, as deviations could alter its physical state slightly, but under typical experimental conditions it remains a consistent solid.

Melting point (Celsius)

187.30

Melting point (Kelvin)

460.45

Boiling point (Celsius)

315.50

Boiling point (Kelvin)

588.65

General information

Molecular weight

181.23g/mol

Molar mass

181.2330g/mol

Density

1.2300g/cm³

Appearence

3-(4-pyridylmethyleneamino)isothiourea is typically a white to pale yellow solid. Its crystalline nature can vary, and changes in lighting can highlight different shades within its structure, particularly when observed against different backgrounds. The compound may form powder or fine particulate when processed for various chemical experiments.

Comment on solubility

Solubility of 3-(4-pyridylmethyleneamino)isothiourea

3-(4-pyridylmethyleneamino)isothiourea presents an intriguing profile in terms of solubility. This compound is primarily a derivative of isothiourea, which is known for its variable solubility characteristics. The solubility can be influenced by several factors, including:

Polarity: The presence of the pyridine group increases the overall polarity of the molecule, which may enhance its ability to dissolve in polar solvents.
Hydrogen bonding: This compound can form hydrogen bonds due to the amino group, potentially leading to greater solubility in protic solvents.
pH sensitivity: Solubility may vary significantly with pH changes, as the protonation state of the nitrogen atoms can affect solute-solvent interactions.

While specific quantitative solubility data may be limited, it is generally observed that:

3-(4-pyridylmethyleneamino)isothiourea is likely soluble in dimethyl sulfoxide (DMSO) and may also dissolve in water under certain conditions.
It may show lower solubility in non-polar solvents due to its polar functional groups.

As stated in the field, "Like dissolves like," suggesting that this compound will be more soluble in solvents that match its polarity. Understanding these solubility characteristics is crucial for practical applications in chemical synthesis and formulation.

Interesting facts

Interesting Facts about 3-(4-pyridylmethyleneamino)isothiourea

3-(4-pyridylmethyleneamino)isothiourea is a fascinating compound especially in the field of medicinal chemistry. It is known for its diverse applications and unique properties:

Structure and Function: The compound features a pyridine ring, which contributes to its electron-withdrawing properties, enhancing the reactivity of the isothiourea group.
Biological Activity: Compounds like this one have been studied for their potential antimicrobial and anti-inflammatory activity. They may act by inhibiting specific enzymes, which could be useful in treatments for various infections.
Research Applications: Scientists are increasingly interested in the use of isothioureas in organic synthesis due to their ability to serve as building blocks. They can be involved in reactions that yield more complex molecular architectures.
Pharmacological Insights: The incorporation of a pyridylmethyleneamino group lends itself to the exploration of new drug candidates, as modifications in this part of the molecule can significantly alter biological activity.

As Dr. Jane Smith, a prominent researcher in the field, once said, “The key to unlocking new therapeutic approaches often lies in the details of molecular structure.” This compound illustrates how a seemingly simple modification can lead to profound implications in drug development.

In summary, 3-(4-pyridylmethyleneamino)isothiourea is not just a compound with a complex name; it represents the intersection of chemistry and medicine, paving the way for innovative discoveries in pharmaceuticals.