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Naphazoline

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Identification
Molecular formula
C14H14N2O
CAS number
550-99-2
IUPAC name
3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylcyclohexa-1,3-dien-1-yl)amino]phenol
State
State

At room temperature, naphazoline is a solid. It is commonly used in solution form in various pharmaceutical preparations.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
368.40
Boiling point (Kelvin)
641.50
General information
Molecular weight
246.32g/mol
Molar mass
246.3210g/mol
Density
1.2220g/cm3
Appearence

Naphazoline typically appears as a white to creamy-white crystalline powder or granules. It is odorless and should be protected from light to prevent discoloration or degradation.

Comment on solubility

Solubility of 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylcyclohexa-1,3-dien-1-yl)amino]phenol

The solubility of 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylcyclohexa-1,3-dien-1-yl)amino]phenol (C14H14N2O) can be quite interesting given its unique molecular structure. Here are some key points to consider regarding its solubility:

  • Polar Nature: The presence of the hydroxyl group (-OH) in the structure suggests that the compound may exhibit some degree of hydrophilicity, which can facilitate its solubility in polar solvents, particularly water.
  • Non-Polar Components: Conversely, the cyclohexadiene and imidazole moieties contribute to a non-polar character, potentially diminishing solubility in polar solvents.
  • Solvent Compatibility: It can be expected that the compound may have varying solubility in different solvents; it might be more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), where the overall balance of polar and non-polar interactions is more favorable.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, enhancing the molecular motion and interactions in a solvent.

In conclusion, the solubility of this compound exemplifies the delicate balance between its polar and non-polar characteristics. As a result, it may exhibit quite variable solubility that is **heavily dependent** on the solvent used and the environmental conditions such as temperature. Always remember the maxim: "Like dissolves like." Thus, careful consideration of solvent selection is crucial when working with this compound.

Interesting facts

Interesting Facts about 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylcyclohexa-1,3-dien-1-yl)amino]phenol

This intriguing compound, with its complex structure, is a subject of interest in various fields of chemistry, particularly in medicinal chemistry and organic synthesis. Here are some key highlights:

  • Innovative Structure: The presence of both an imidazole ring and a phenolic group contributes to its unique chemical properties, allowing it to interact with biological targets in novel ways.
  • Potential Biological Activity: Compounds with similar structures to this one have been investigated for their potential pharmacological activities, including antimicrobial, anti-inflammatory, and anticancer properties.
  • Versatile Synthesis: The synthesis of this compound encompasses multi-step organic reactions, providing an excellent case study for students interested in organic chemistry methodologies and reaction mechanisms.
  • Application in Research: Researchers utilize compounds like this to explore new drug prototypes and understand interactions at a molecular level, which is vital for drug development.
  • Imidazole's Influence: The imidazole moiety is known for its role in many biological systems, such as in amino acids like histidine, which emphasizes the potential significance of this compound in biochemical pathways.

The complexity and versatility of 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylcyclohexa-1,3-dien-1-yl)amino]phenol make it a captivating topic for both research and education in the field of chemistry. As with many organic compounds, understanding its behavior can lead to advancements in various scientific domains.

Synonyms
Bio1_001136
CBiol_001872
KBioGR_000155
KBioSS_000155
KBio2_000155
KBio2_002723
KBio2_005291
KBio3_000309
KBio3_000310
Bio1_000158
Bio1_000647
Bio2_000155
Bio2_000635
IDI1_033905