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Nifuroxazide

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Identification
Molecular formula
C12H9N3O5
CAS number
965-52-6
IUPAC name
3-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-2-oxo-4H-imidazol-5-olate
State
State

Nifuroxazide is solid at room temperature.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
275.22g/mol
Molar mass
275.2250g/mol
Density
1.5740g/cm3
Appearence

Nifuroxazide is typically a yellow crystalline powder that is light-sensitive. It may appear as a solid granule and has a characteristic color due to the presence of nitro and other functional groups in its structure.

Comment on solubility

Solubility of 3-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-2-oxo-4H-imidazol-5-olate

The solubility of 3-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-2-oxo-4H-imidazol-5-olate (C12H9N3O5) can be influenced by several factors, which contribute to its behavior in various solvents. This compound contains both polar and non-polar functional groups, leading to unique solubility characteristics.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar nitro groups and possible hydrophilic nitrogen atoms can enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the imidazole moiety may also facilitate solubility in aqueous environments.
  • Stacking Interactions: Aromatic rings, particularly the presence of furyl and phenyl groups, might lead to stacking interactions, which could hinder solubility in some organic solvents.

In general, while this compound may show moderate solubility in water and polar organic solvents, it may encounter challenges dissolving in non-polar solvents. As a rule of thumb, "like dissolves like," indicating that compounds with similar polarities tend to be more soluble in one another.

For practical applications, knowing the solubility of such compounds is crucial, as it can influence their bioavailability, reactivity, and utility in various formulations. Testing in different solvents would be advisable to ascertain the best conditions for achieving optimal solubility.

Interesting facts

Interesting Facts about 3-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-2-oxo-4H-imidazol-5-olate

This intriguing compound belongs to a class of chemical structures that exhibit a diverse range of biological activities, making it a topic of interest in both medicinal and organic chemistry. Here are some fascinating points to consider:

  • Biological Significance: Compounds like this one are often investigated for their potential therapeutic properties, including antibacterial and anticancer activities. The presence of the nitrophenyl group may enhance such functionalities.
  • Structure-Activity Relationship: The unique fusion of the imidazole ring with the furan moiety provides a rich platform for researchers to study how structural variations impact biological activity.
  • Versatility in Synthesis: This compound can be synthesized through various organic reactions, which is a valuable method for students and scientists to explore developing new derivatives for pharmaceutical applications.
  • Innovation in Drug Development: As research continues, modifications to compounds like this one can lead to the discovery of novel drugs that target specific biological pathways.
  • Interdisciplinary Relevance: Understanding this compound’s properties requires knowledge spanning multiple scientific fields, including organic chemistry, pharmacology, and biochemistry.

In summary, 3-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-2-oxo-4H-imidazol-5-olate stands out not just for its structural complexity but also for the potential it holds in contributing to advancements in medicinal chemistry. As one quote perfectly captures the essence of scientific adventure: "Every compound is a doorway into the complexities of nature."

Synonyms
dantrolene(1-)
3-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate
dantrolene anion
CHEBI:59697
Q27126857
1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin anion
3-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)-2,5-dioxoimidazolidin-1-ide