Skip to main content

Erlotinib

ADVERTISEMENT
Identification
Molecular formula
C22H23ClN2O4
CAS number
183321-74-6
IUPAC name
3-[5-chloro-2-(2-morpholinoethoxy)phenyl]-1-(3,4-dimethoxyphenyl)prop-2-en-1-one
State
State

Erlotinib is a solid at room temperature, often handled as a powder for pharmaceutical applications.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
740.50
Boiling point (Kelvin)
1 013.65
General information
Molecular weight
393.89g/mol
Molar mass
393.8240g/mol
Density
1.3389g/cm3
Appearence

Erlotinib appears as a white to yellow powder, often used in its hydrochloride form, which enhances its solubility for medical applications. The compound is typically administered in pharmaceutical formulations.

Comment on solubility

Solubility Insights

The solubility of the compound 3-[5-chloro-2-(2-morpholinoethoxy)phenyl]-1-(3,4-dimethoxyphenyl)prop-2-en-1-one can be characterized as follows:

  • Polarity: The presence of various functional groups, including the morpholino and dimethoxy groups, suggests that this compound may exhibit moderate polarity. This often influences its solubility in different solvents.
  • Solvent Interaction: Given its molecular structure, the compound is likely to be soluble in:
    • Apolar solvents - Due to hydrophobic aromatic rings.
    • Polar organic solvents - Such as ethanol or dimethyl sulfoxide (DMSO), which can interact harmoniously with the polar regions of the molecule.
  • Less Likely to be Soluble: It may exhibit low solubility in:
    • Water - The bulky structure and presence of apolar regions hinder full solvation in polar water.
    • Highly nonpolar solvents - Such as hexane or octane, which lack the ability to disrupt the molecular interactions present in this compound.

In summary, the solubility of 3-[5-chloro-2-(2-morpholinoethoxy)phenyl]-1-(3,4-dimethoxyphenyl)prop-2-en-1-one is influenced by its chemical interactions and the solvent used. Understanding these properties is crucial for applications in pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 3-[5-Chloro-2-(2-morpholinoethoxy)phenyl]-1-(3,4-dimethoxyphenyl)prop-2-en-1-one

This fascinating compound belongs to the class of chalcones, which are known for their unique chemical structures and diverse biological activities. Chalcones have garnered significant interest in the field of medicinal chemistry due to their potential therapeutic properties. Here are some intriguing aspects to consider:

  • Biological Activity: Many chalcones exhibit promising antimicrobial and anti-inflammatory properties, making them valuable in drug discovery and development.
  • Pharmacological Potential: This compound may possess anti-cancer effects. Research suggests that certain chalcones can inhibit tumor growth and promote apoptosis in cancer cells.
  • Structural Diversity: The presence of functional groups, such as chloro and morpholinoethoxy, can significantly influence the compound's biological activity and interaction with biological targets.
  • Synthetic Versatility: Chalcones can be synthesized via various methods, often involving cross-coupling techniques or condensation reactions. This versatility opens doors for exploring related compounds with tailored medicinal properties.
  • Research Interest: As indicated in recent studies, the investigation of chalcones continues to expand, positioning them as a focal point in the search for novel therapeutic agents.

In summary, the compound not only exemplifies the rich diversity of chalcones but also highlights the intricate relationship between chemical structure and biological function. The ongoing research into such compounds reinforces their significance in advancing our understanding of medicinal chemistry and the development of new therapeutic strategies.