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Cefazolin

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Identification
Molecular formula
C14H14N8O4S3
CAS number
25953-19-9
IUPAC name
3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, Cefazolin is typically in a solid state. As a powder, it needs to be reconstituted into a liquid form for injection purposes.

Melting point (Celsius)
198.50
Melting point (Kelvin)
471.65
Boiling point (Celsius)
201.50
Boiling point (Kelvin)
474.65
General information
Molecular weight
454.50g/mol
Molar mass
454.4970g/mol
Density
1.5400g/cm3
Appearence

Cefazolin typically appears as a white to off-white crystalline powder. It may also be hygroscopic in nature, requiring protection from moisture.

Comment on solubility

Solubility of 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility profile of the compound with the formula C14H14N8O4S3 is intriguing and multifaceted. Understanding its solubility is essential for applications in pharmaceuticals and other industries. Here are some key points regarding its solubility:

  • Polar Nature: The presence of multiple functional groups such as carboxylate and thiadiazole suggests that the compound may exhibit polar characteristics, which often enhances solubility in polar solvents.
  • Hydrophilicity: With the inclusion of amine and carboxylic acid functionalities, the compound is likely to have increased hydrophilicity, promoting solubility in aqueous solutions.
  • Solvent Dependency: The solubility could vary significantly depending on the solvent used, potentially being more soluble in solvents like dichloromethane and less soluble in non-polar solvents.
  • pH Influence: The solubility may also be influenced by pH levels due to the ionizable nature of its acidic functional groups.

Furthermore, it is essential to note that the presence of sulfur atoms in the structure can affect solubility due to their unique interactions with solvents and other solutes. Therefore, the solubility of this compound could be described as a complex interplay of chemical structure and environmental factors, warranting further investigation to fully understand its behavior in various formulations.

Interesting facts

Interesting Facts About 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This intriguing compound exhibits a complex structure that is notable for several reasons:

  • Biological Significance: Compounds like this one often play essential roles in pharmaceuticals. They can potentially serve as antimicrobial agents or in the treatment of various diseases, given their unique functional groups.
  • Diverse Functional Groups: The presence of both thiadiazole and tetrazole rings adds significant diversity to its chemical behavior. Each of these groups can impart unique properties that may interact with biological systems in distinct ways.
  • Structural Complexity: The bicyclic structure indicates a fascinating arrangement of atoms which can be explored for strain energy and reactivity. Indeed, the 1-azabicyclo[4.2.0] motif suggests unique mechanisms of action in biological systems.
  • Synthetic Versatility: The synthesis routes to create such complex compounds can involve advanced chemical methodologies, making them a valuable subject of study for synthetic chemists.
  • Research Potential: Ongoing studies into derivatives of this compound could lead to the development of new drugs, especially in the realm of antibiotic resistance where new solutions are critically needed.

As a chemist or student, delving into the intricacies of such compounds can be both challenging and rewarding. Always remember the words of the great chemist Linus Pauling: "The best way to have a good idea is to have a lot of ideas." Exploring compounds like this one can lead to innovative breakthroughs in the pharmaceutical realm.

Synonyms
3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
STK030845
AKOS000715076
AKOS022012512
3-{[(5-METHYL-1,3,4-THIADIAZOL-2-YL)SULFANYL]METHYL}-8-OXO-7-[2-(1H-1,2,3,4-TETRAZOL-1-YL)ACETAMIDO]-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE