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Nitrofurantoin

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Identification
Molecular formula
C13H8N2O4
CAS number
67-20-9
IUPAC name
3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one
State
State

At room temperature, Nitrofurantoin is usually a solid, present in the form of a crystalline powder. It is poorly soluble in water, which affects its bioavailability when used in pharmaceuticals.

Melting point (Celsius)
271.00
Melting point (Kelvin)
544.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
238.17g/mol
Molar mass
238.1680g/mol
Density
1.4731g/cm3
Appearence

Nitrofurantoin generally appears as a yellow crystalline powder with a slightly bitter taste. It is often used in its monohydrate form in pharmaceuticals for stability and ease of processing.

Comment on solubility

Solubility of 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one

The compound 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one displays unique solubility characteristics that are influenced by its aromatic and nitro functional groups.

Solubility Insights

The solubility of this compound can be described in the following ways:

  • Polar and Non-Polar Interaction: Due to the presence of the nitro group, which is polar, and the aromatic structures, the compound exhibits limited solubility in non-polar solvents while showing better solubility in polar solvents such as water and ethanol.
  • Temperature Dependency: The solubility may vary with temperature, typically increasing with higher temperatures due to enhanced molecular motion that aids dissolution.
  • pH Influence: The solubility can also be affected by the pH of the solvent; in acidic conditions, the compound is more likely to be protonated, potentially enhancing solubility.

In summary, the solubility behavior of 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one is a balance between its polar and non-polar characteristics, influenced by various external factors such as temperature and pH levels. Understanding these aspects is crucial when considering its applications in chemical reactions and formulations.

Interesting facts

Interesting Facts about 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one

The compound 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one, also known in some communities as an important *intermediate* in organic synthesis, exhibits several fascinating characteristics that merit exploration.

Noteworthy Attributes

  • Component Diversity: This compound boasts a rich structure that combines both *furan* and *phenyl* rings, making it a unique target for various chemical reactions.
  • Bioactivity: The presence of a nitro group can often influence biological activity, leading to interest in its potential applications in pharmaceuticals, particularly in drug design and development.
  • Electrophilic Character: Due to the presence of the α,β-unsaturated carbonyl moiety, this compound can engage in various electrophilic reactions, making it a versatile substrate in organic chemistry.

Applications in Research

Scientists have found that compounds like 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one can be pivotal in:

  • Investigating mechanisms of *enzyme catalysis*.
  • Servicing as *probes* in biological studies.
  • Acting as precursors in the synthesis of more complex molecules.

Quote from the Field

As one researcher aptly stated, "Understanding the reactivity of compounds with complex structures reveals the underlying beauty of organic chemistry."

In conclusion, 3-(5-nitro-2-furyl)-1-phenyl-prop-2-en-1-one is more than just a name; it embodies a foundation for ongoing study and innovation in the realm of chemistry. Its diverse reactions and potential applications highlight the ever-evolving landscape of scientific inquiry.

Synonyms
3-(5-Nitro-2-furanyl)-1-phenyl-2-propen-1-one
4332-88-1
DTXSID701253574
CID 20331
AKOS030662042
UPCMLD0ENAT5762466:001