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Nitrofurazone

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Identification
Molecular formula
C6H6N4O4S
CAS number
59-87-0
IUPAC name
3-[(5-nitro-2-furyl)methyleneamino]isothiourea
State
State

At room temperature, Nitrofurazone is typically in a solid state. It is not very soluble in water but can dissolve in dimethyl sulfoxide (DMSO) and other organic solvents. Due to its solid form, it is usually applied in various formulations such as creams or ointments for medicinal use.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
198.20g/mol
Molar mass
198.1600g/mol
Density
1.6800g/cm3
Appearence

Nitrofurazone is a yellow, crystalline solid. It often appears as a bright yellow powder or as bright yellow crystals, making it visually distinctive.

Comment on solubility

Solubility of 3-[(5-nitro-2-furyl)methyleneamino]isothiourea

The solubility of 3-[(5-nitro-2-furyl)methyleneamino]isothiourea can be influenced by several factors, primarily relating to its chemical structure and functional groups. This compound, featuring a furyl ring and isothiourea moiety, typically exhibits the following solubility characteristics:

  • Polarity: The presence of nitro and amino groups can lead to increased polarity, which may enhance solubility in polar solvents like water.
  • Hydrogen bonding: The amino group can participate in hydrogen bonding, further aiding in solvation in appropriate solvents.
  • Solvent interactions: The compound may show variable solubility in organic solvents such as DMSO or methanol due to structural compatibility.

Overall, in general, many isothiourea derivatives have moderate to high solubility in polar solvents, while their solubility in non-polar solvents is typically lower.
The exact solubility of this specific compound may vary and should be determined experimentally, as it can be affected by factors such as:

  • Temperature: Higher temperatures often increase solubility.
  • pH levels: Changes in pH can affect ionization states, influencing solubility.

In summary, while 3-[(5-nitro-2-furyl)methyleneamino]isothiourea is expected to have a reasonable solubility profile in polar solvents, precise data should be acquired through solubility testing under various conditions to confirm its behavior in different environments.

Interesting facts

Interesting Facts about 3-[(5-nitro-2-furyl)methyleneamino]isothiourea

3-[(5-nitro-2-furyl)methyleneamino]isothiourea is a fascinating compound that showcases the intricate relationship between organic chemistry and biological activity. Here are several engaging insights into this compound:

  • Biological Relevance: This compound has been studied for its potential pharmaceutical applications, particularly because of the presence of the nitro group, which is known to enhance the biological activity of compounds.
  • Versatile Use: The isothiourea moiety is significant in medicinal chemistry, often leading to the development of inhibitors for various biological targets, including enzymes and receptors.
  • Furan Derivatives: The 5-nitro-2-furyl unit is of particular interest due to its ability to participate in various chemical reactions, making it a key building block in the synthesis of more complex molecules.
  • Synthetic Pathways: Scientists are fascinated by the synthetic routes that lead to the formation of this compound. The unique combination of functional groups often requires innovative and efficient synthetic methodologies.
  • Further Research: Ongoing research continues to explore the mechanisms of action and effectiveness of compounds like 3-[(5-nitro-2-furyl)methyleneamino]isothiourea in combating diseases, highlighting the ever-evolving nature of medicinal chemistry.

In summary, 3-[(5-nitro-2-furyl)methyleneamino]isothiourea not only represents a significant chemical entity, but it also embodies the dynamic interplay between synthesis and biological application, making it a worthy subject of study for chemists and biologists alike.