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Desipramine

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Identification
Molecular formula
C18H22N2
CAS number
50-47-5
IUPAC name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine
State
State

At room temperature, desipramine is typically in a solid state. It is a crystalline compound.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.15
Boiling point (Celsius)
440.00
Boiling point (Kelvin)
713.15
General information
Molecular weight
266.39g/mol
Molar mass
266.3800g/mol
Density
1.4000g/cm3
Appearence

Desipramine typically appears as a white to off-white crystalline solid. It is usually odorless.

Comment on solubility

Solubility of 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine (C18H22N2)

The solubility of organic compounds, such as 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine, is influenced by various factors. Given its molecular structure, we may consider the following aspects:

  • Polarity: The presence of nitrogen atoms typically increases polarity, which can enhance solubility in polar solvents such as water.
  • Hydrophobic Interactions: The hydrophobic regions from the hydrocarbon chains can limit solubility in highly polar solvents.
  • Temperature: Solubility may increase with temperature, so the conditions under which the compound is dissolved can greatly impact outcomes.
  • pH Levels: The ionization state of the compound can change with pH, affecting its solubility profile. Basic or acidic conditions can lead to variable solubility.

In practical applications, it is essential to consider these factors to predict solubility. As an interesting observation, many drugs with a similar structure tend to have varying solubility in aqueous solutions due to these dynamics. For instance, one might note that "the solubility of a compound" often fails to exhibit a straightforward behavior, thus requiring specific conditions to fully understand its characteristics. In the case of 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine, its solubility may need to be assessed in both polar and non-polar solvents to determine its practical use.

Interesting facts

Interesting Facts about 3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine

This compound, often referred to as a novel pharmacological agent, belongs to a class of molecules that exhibit potential therapeutic effects. It features a unique structure that makes it a subject of interest in medicinal chemistry. Here are some key points to consider:

  • Structure Complexity: The intricate arrangement of its molecular structure is indicative of its potential interactions with biological targets. The presence of a benzene ring fused to a bicyclic system is a fascinating aspect that contributes to its chemical properties.
  • Pharmacological Potential: Compounds like this have been studied for their neuroactive properties, potentially influencing neurotransmitter systems in the brain. Such effects can unveil new avenues for treating neurological disorders.
  • Dimethylamine Group: The N,N-dimethyl group in the compound enhances its lipophilicity, which can influence how the compound interacts with cell membranes and its overall bioavailability.
  • Research Significance: Due to its unique chemical features, compounds of this nature are often investigated for their capacity to act as lead compounds in drug discovery, often inspiring further synthetic modifications to enhance their efficacy and selectivity.

As a chemistry student, it’s intriguing to delve into the synthesis strategies that lead to such complex compounds. The challenges presented in creating these molecules provide valuable learning experiences in the field of organic synthesis. Understanding the implications of particular structural features on biological activity is crucial in the journey to develop new medications.

In summary, 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine is a compelling compound that embodies the intersection between chemistry and pharmacology, showcasing how structural variations can lead to significant biological implications.

Synonyms
imipramine
50-49-7
Melipramine
Antideprin
Berkomine
Imidobenzyle
Dimipressin
Melipramin
Dynaprin
Intalpram
Nelipramin
Timolet
Irmin
Dpid
Dyna-zina
Tofranil
Impramine
Censtim
Censtin
Imiprin
Promiben
Iramil
Imipramina
Janimine
Imipraminum
Declomipramine
Eupramin
Imipramin
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Imizine
Surplix
Imizin
Tofranil, base
Psychoforin
Imavate
Cristalia
Sermonil
N-(gamma-Dimethylaminopropyl)iminodibenzyl
N-(3-Dimethylaminopropyl)-o-iminodibenzyl
2,2'-(3-Dimethylaminopropylimino)bibenzyl
2,2'-(3-Dimethylaminopropylimino)dibenzyl
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Imipraminum [INN-Latin]
Imipramina [INN-Spanish]
Imizinum
Tofranil (free base)
SK-Pramine
CCRIS 9173
NSC 169866
HSDB 3100
1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine
UNII-OGG85SX4E4
5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
EINECS 200-042-1
OGG85SX4E4
Imipramine (INN)
NSC-169866
BRN 0256892
5,6-Dihydro-N-(3-(dimethylamino)propyl)-11H-dibenz(b,e)azepine
5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
DTXSID1043881
CHEBI:47499
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
ORG-2463
CHEMBL11
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-
N-(.gamma.-Dimethylaminopropyl)iminodibenzyl
DTXCID9023881
5,e)azepine
5,e]azepine
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-
NSC169866
NCGC00015563-07
Imipramina [Italian]
IMIPRAMINE [INN]
Tofranil (TN)
10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine
3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
Imipraminum (INN-Latin)
Imipramina (INN-Spanish)
Imipramine [INN:BAN]
N,N-Dimethyl-10,11-dihydro-5H-dibenzo[b,f]azepine-5-propanamine-2,8-D2
IMIPRAMINE (MART.)
IMIPRAMINE [MART.]
IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D
2241983-10-6
3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)propyldimethylamine
5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
CAS-50-49-7
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine;3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine
Janimine (hydrochloride)
Tofranil (hydrochloride)
CAS-113-52-0
TRIMIPRAMINE MALEATE IMPURITY D (EP IMPURITY)
TRIMIPRAMINE MALEATE IMPURITY D [EP IMPURITY]
5H-Dibenz(b, 5-(3-(dimethylamino)propyl)-10,11-dihydro-
5H-Dibenz[b, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
Tofranil base
10,11-dihydro-N,N-dimethyl-5H-dibenz(b,f)azepine-5-propanamine
3-(5H-DIBENZO(B,F)AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropan-1-amine
5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
IXX
Imizin (Salt/Mix)
Imavate (Salt/Mix)
Imizine (Salt/Mix)
Surplix (Salt/Mix)
Eupramin (Salt/Mix)
Imizinum (Salt/Mix)
Tofranil (Salt/Mix)
Spectrum_000915
IMIPRAMINE [MI]
Psychoforin (Salt/Mix)
Prestwick0_000072
Prestwick1_000072
Prestwick2_000072
Prestwick3_000072
SK-Pramine (Salt/Mix)
Spectrum2_000990
Spectrum3_000466
Spectrum4_000016
Spectrum5_000864
IMIPRAMINE [HSDB]
Lopac-I-7379
IMIPRAMINE [VANDF]
IMIPRAMINE [WHO-DD]
Lopac0_000702
Oprea1_200908
SCHEMBL34282
BSPBio_000283
BSPBio_002172
GTPL357
KBioGR_000391
KBioSS_001395
BIDD:GT0116
DivK1c_000559
SPBio_001059
SPBio_002204
G-22355 (Salt/Mix)
BPBio1_000313
HY-B1490A
KBio1_000559
KBio2_001395
KBio2_003963
KBio2_006531
KBio3_001392
N06AA02
NINDS_000559
HMS2089G08
Tox21_110174
BDBM50010859
CCG-36485
MFCD31699979
STL416211
AKOS016010320
Tox21_110174_1
DB00458
SDCCGSBI-0050680.P005
IDI1_000559
MRF-0000592
NCGC00015563-01
NCGC00015563-02
NCGC00015563-03
NCGC00015563-04
NCGC00015563-05
NCGC00015563-06
NCGC00015563-08
NCGC00015563-09
NCGC00015563-10
NCGC00015563-11
NCGC00015563-13
NCGC00015563-25
NCGC00024253-03
NCGC00024253-04
5-(3-Dimethylaminopropyl)-10,f)azepine
DA-69850
FI176386
SY246340
Trimipramine maleate impurity, imipramine-
SBI-0050680.P004
WLN: T C676 BN&T&J B3N1&1
5-(3-(Dimethylamino)propyl)-10,f)azepine
AB00053486
CS-0013621
NS00008106
5H-Dibenz[b, 10,11-dihydro-N,N-dimethyl-
C07049
D08070
EN300-708790
G82405
Q58396
AB00053486-15
AB00053486_16
AB00053486_17
1-(3-Dimethylaminopropyl)-4,3,6,7-dibenzazepine
L000739
BRD-K38436528-003-05-5
BRD-K38436528-003-15-4
BRD-K38436528-003-25-3
BRD-K38436528-003-26-1
BRD-K38436528-003-27-9
5H-Dibenz(b, 10,11-dihydro-5-(3-(dimethylamino)propyl)-
CLOMIPRAMINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
TRIMIPRAMINE MALEATE IMPURITY, IMIPRAMINE-(USP IMPURITY)
5H-Dibenz[b,f]azepine, 5-(dimethylamino)propyl-10,11-dihydro-
TRIMIPRAMINE MALEATE IMPURITY, IMIPRAMINE- [USP IMPURITY]
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine #
(3-{2-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine
(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine
200-042-1
InChI=1/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H