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Clomipramine Hydrochloride

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Identification
Molecular formula
C19H23ClN2
CAS number
17321-77-6
IUPAC name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine;hydrochloride
State
State

At room temperature, Clomipramine Hydrochloride is a stable solid. It is typically provided in the form of tablets for medical use.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
351.27g/mol
Molar mass
351.2640g/mol
Density
1.1600g/cm3
Appearence

Clomipramine hydrochloride appears as a white or off-white crystalline powder. It is hydroscopic and may have a faint, characteristic odor.

Comment on solubility

Solubility of 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine; hydrochloride

The solubility of the compound 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine; hydrochloride can be influenced by various factors, making it an interesting subject for exploration:

  • Influence of Hydrochloride Form: As a hydrochloride salt, this compound is likely to exhibit enhanced solubility in polar solvents, particularly in water due to the ionic nature of the salt.
  • Temperature Effects: It is important to note that solubility can vary with temperature; generally, an increase in temperature may lead to an increase in solubility for many compounds.
  • pH Dependence: The solubility can also be pH-dependent. Being a salt, it may exhibit different solubility profiles under varying pH conditions, especially when considering biological relevance.
  • Structural Characteristics: The presence of both hydrophobic and hydrophilic regions in the molecular structure suggests a potential for moderate solubility in organic solvents as well.

In summary, one could consider that “the solubility of this compound is likely to be enhanced in water and other polar solvents due to its hydrochloride nature,” but this can be influenced by environmental conditions such as temperature and pH. Further empirical studies would provide more accurate data on its solubility characteristics.

Interesting facts

Interesting Facts about 3-(5,6-dihydrobenzo[[1]]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine; hydrochloride

This compound is a fascinating example of a pharmaceutical agent that exhibits a unique structure and potential therapeutic effects. Here are some compelling points to consider:

  • Pharmacological Interest: The compound's structural features, including the benzazepine framework, have drawn significant attention for their potential role in modulating neurotransmitter systems.
  • Derived Applications: Due to its unique properties, this compound may be explored for its use in treating various neurological and psychiatric disorders.
  • Synthetic Pathways: The synthesis of this compound presents interesting challenges in organic chemistry, showcasing the complexity of multi-step reactions and the importance of stereochemistry.
  • Research Potential: Ongoing research into compounds like this one highlights the importance of understanding structure-activity relationships in drug design. It emphasizes how small alterations to a compound's structure can lead to different biological activities.

Moreover, the compound demonstrates how interdisciplinary approaches, integrating chemistry, pharmacology, and neuroscience, are vital for advancing our understanding of drug action and development. As one researcher put it, “The nuances of chemical structures in medicinal chemistry are often the key that unlocks new therapeutic potentials.”

In summary, 3-(5,6-dihydrobenzo[[1]]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine; hydrochloride is not just a complex chemical entity; it embodies the convergence of theoretical knowledge and practical application in the quest for innovative therapies.

Synonyms
Imipramine hydrochloride
113-52-0
Imipramine Hcl
Tofranil
Chimoreptin
Chrytemin
Presamine
Pryleugan
Deprinol
Feinalmin
Imilanyle
Iprogen
Persamine
Pertofram
Pramine
Teperine
Tofranile
Imizine
IMP hydrochloride
IA-Pram
Psicopramine
Dynazina
Efuranol
Fujisawa
Imipramini
Thymopramin
Tipramine
Imidol
Janimine
Odeoxil
Venefon
Vionyl
Co cap imipramine 25
Antideprin hydrochloride
Imipramini hydrochloridum
Psychoforin
Imavate
Imizin
Imipram
Imipramine monohydrochloride
Melipramine HCl
SK-Pramine hydrochloride
Imizinum
MFCD00012669
UNII-BKE5Q1J60U
EINECS 204-030-7
BKE5Q1J60U
NSC 114900
NSC-114900
CHEBI:5882
G 22355
DTXSID7040738
N-(3-Dimethylaminopropyl)iminodibenzyl hydrochloride
Imipramine (hydrochloride)
5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride
N-(gamma-Dimethylaminopropyl)iminodibenzyl hydrochloride
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride
MLS000028430
Imipramine.HCl
DTXCID5020738
Imipramine hydrochloride [USP:JAN]
5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz(b,f)azepine hydrochloride
NSC114900
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-, hydrochloride
N-(gamma-Dimetilaminopropil)-iminodibenzile cloridrato
SK-Pramine
SMR000058388
Tofranil (TN)
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-, monohydrochloride
5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride
G-22355
Imipramine hydrochloride (USP:JAN)
IMIPRAMINE HYDROCHLORIDE (MART.)
IMIPRAMINE HYDROCHLORIDE [MART.]
IMIPRAMINE HYDROCHLORIDE (USP-RS)
IMIPRAMINE HYDROCHLORIDE [USP-RS]
Imipramine hydrochloride [JAN]
IMIPRAMINE HYDROCHLORIDE (EP MONOGRAPH)
IMIPRAMINE HYDROCHLORIDE (USP IMPURITY)
IMIPRAMINE HYDROCHLORIDE (USP MONOGRAPH)
IMIPRAMINE HYDROCHLORIDE [EP MONOGRAPH]
IMIPRAMINE HYDROCHLORIDE [USP IMPURITY]
IMIPRAMINE HYDROCHLORIDE [USP MONOGRAPH]
Melipramine hydrochloride
SR-01000003064
CAS-113-52-0
3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride
SK-Pramine HCl
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride;Chrytemin;Imiprin
Prestwick_277
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine
CPD000058388
3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropan-1-aminium chloride
Opera_ID_319
N-(gamma-Dimetilaminopropil)-iminodibenzile cloridrato [Italian]
SureCN41766
Imipramine hydrochloride rs
CHEMBL1692
G 22150
REGID_for_CID_8228
SCHEMBL41765
MLS001146891
MLS002222195
SPECTRUM1500348
HY-B1490R
Imipramine for system suitability
HMS1568O05
HMS1920F17
Pharmakon1600-01500348
HY-B1490
Imipramine HCl - Bio-X trade mark
Tox21_301417
Tox21_500702
CCG-40208
IMIPRAMINE HYDROCHLORIDE [MI]
NSC757074
s4377
Imipramine hydrochloride (JP17/USP)
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
AKOS015895330
Imipramine (hydrochloride) (Standard)
AC-7587
CS-6180
FI24561
KS-1072
LP00702
NC00570
NSC-757074
5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
IMIPRAMINE HYDROCHLORIDE [VANDF]
IMIPRAMINE HYDROCHLORIDE [WHO-DD]
IMIPRAMINE HYDROCHLORIDE [WHO-IP]
NCGC00024253-05
NCGC00094054-01
NCGC00094054-02
NCGC00094054-03
NCGC00094054-04
NCGC00094054-05
NCGC00255651-01
NCGC00261387-01
BI164574
Imipramine hydrochloride, >=99% (TLC)
SY113894
DB-041172
EU-0100702
I0971
NS00079397
ST50985122
SW196582-4
IMIPRAMINE HYDROCHLORIDE [ORANGE BOOK]
C07982
D00815
EN300-123017
I 7379
IMIPRAMINI HYDROCHLORIDUM [WHO-IP LATIN]
Imipramine hydrochloride, BioXtra, >=99% (TLC)
Imipramine hydrochloride, Sigma Reference Standard
Imipramine.HCl, 1mg/ml in Methanol (as free base)
SR-01000003064-2
SR-01000003064-7
5-(3-dimethylaminopropyl)-10,f)azepine hydrochloride
Q27106923
WLN: T C676 BN & T & J B3N1 & 1 & GH
Z1546610478
N-(.gamma.-Dimethylaminopropyl)iminodibenzyl hydrochloride
5H-Dibenz[b, 10,11-dihydro-N,N-dimethyl-, monohydrochloride
Imipramine Hydrochloride 1.0 mg/ml in Methanol (as free base)
5H-Dibenz[b, 10,11-dihydro-5-[3-(dimethylamino)propyl]-, hydrochloride
Imipramine hydrochloride, European Pharmacopoeia (EP) Reference Standard
10,11-Dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-5-propanamine Hydrochloride
3-(10,11-Dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropylamine monohydrochloride
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine Hydrochloride
5-(3-Dimethylaminopropyl)-10,11-dihydro-5h-dibenz-[b,f]-azepine, hydrochloride
5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine Hydrochloride
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride (1:1)
5H-Dibenz[b, 5-[3-(dimethylamino)propyl]-10,11-dihydro-, monohydrochloride
Imipramine for system suitability, European Pharmacopoeia (EP) Reference Standard
Imipramine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Imipramine hydrochloride, United States Pharmacopeia (USP) Reference Standard
(3-{2-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine hydrochloride
204-030-7