Skip to main content

Iodixanol

ADVERTISEMENT
Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-oxo-hexanoyl]amino]-2,4,6-triiodo-benzoic acid;6-(methylamino)hexane-1,2,3,4,5-pentol
State
State

At room temperature, Iodixanol is typically found as a solid. However, it is commonly used in a formulated aqueous solution as a non-ionic, isotonic contrast media for medical imaging.

Melting point (Celsius)
164.00
Melting point (Kelvin)
437.15
Boiling point (Celsius)
155.20
Boiling point (Kelvin)
428.30
General information
Molecular weight
1550.20g/mol
Molar mass
1 550.1980g/mol
Density
2.3000g/cm3
Appearence

Iodixanol is a white to off-white crystalline powder. It is often described as hygroscopic and is sometimes encountered as a solution for use as a contrast agent in imaging procedures.

Comment on solubility

Solubility of 3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-oxo-hexanoyl]amino]-2,4,6-triiodo-benzoic acid; 6-(methylamino)hexane-1,2,3,4,5-pentol

The solubility characteristics of this complex compound are of great interest due to its intricate structure, which features both hydrophilic and hydrophobic elements. Let's explore its solubility in detail:

  • Hydrophilic nature: The presence of carboxylic acid and multiple hydroxyl (-OH) groups suggests that this compound is likely to exhibit considerable solubility in polar solvents, especially water.
  • Iodine substituents: The multiple iodine atoms introduce significant steric hindrances that may affect solubility, potentially making the compound less soluble in non-polar solvents.
  • Interactions: The ability to form hydrogen bonds due to the amino and hydroxyl groups enhances solvation in aqueous environments.
  • Temperature effects: Solubility may increase with temperature, as is common with many organic compounds, potentially leading to more efficient dissolution in solvents.

In conclusion, while the precise solubility of this compound may vary depending on specific conditions, one can generally expect a higher solubility in water due to its polar functional groups. Further experimental studies are essential to quantify its solubility accurately under varied conditions.

Interesting facts

Interesting Facts about 3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-oxo-hexanoyl]amino]-2,4,6-triiodo-benzoic acid; 6-(methylamino)hexane-1,2,3,4,5-pentol

This intriguing compound combines the properties of both an aromatic carboxylic acid and a complex hexane derivative, which opens a portal to fascinating applications in medicinal chemistry and materials science. Here are some notable aspects:

  • Iodine Incorporation: The presence of 3-triiodinated aniline functionalities suggests significant analytical and imaging potential. Iodine-containing compounds are often explored in the realm of radiology due to their high atomic number, making them effective contrast agents in imaging techniques.
  • Biological Relevance: The molecular structure of this compound showcases building blocks that lend themselves to various biological interactions. Compounds such as these are frequently studied for their potential as therapeutic agents, particularly in cancer treatment.
  • Amine Functionalities: The presence of methylamino groups is crucial for enhancing solubility and bioavailability, which are critical factors in drug design. This modification can improve the affinity of the compound for biological targets significantly.
  • Colorimetric Properties: The complex arrangement of aromatic rings in the structure allows for unique colorimetric properties. Such traits make it useful in developing pH indicators or chemical sensors.

Researchers admire this compound for its structural complexity and the potential pathways it opens for further development. As stated in one study, "The integration of triiodinated moieties in medicinal compounds not only enhances their functionality but also their visibility in biological systems."

In summary, 3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-oxo-hexanoyl]amino]-2,4,6-triiodo-benzoic acid; 6-(methylamino)hexane-1,2,3,4,5-pentol stands at the crossroads of chemistry and medicine, presenting numerous opportunities for innovation and discovery.

Synonyms
Adipiodone, dimeglumine salt
Endocistobil;Endografin
Iodipamide (meglumine)
3-[[6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoic acid;6-(methylamino)hexane-1,2,3,4,5-pentol
SCHEMBL14973499