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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
3-(6-methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid
State
State

Naproxen is typically found as a solid at room temperature, specifically in a crystalline powder form.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
230.26g/mol
Molar mass
230.2590g/mol
Density
1.1250g/cm3
Appearence

Naproxen appears as a white to off-white crystalline powder. It is practically odorless and is often used in its sodium salt form, which is more easily absorbed by the body.

Comment on solubility

Solubility of 3-(6-methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid

The solubility of 3-(6-methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid can be quite intriguing due to its complex structure. This compound, containing a naphthalene ring, often shows a varied solubility profile affected by several factors:

  • Solvent Composition: The solubility is generally higher in organic solvents compared to polar solvents like water due to the non-polar nature of the naphthyl moiety.
  • Temperature Variation: Increased temperatures typically enhance solubility for many organic acids, making it crucial to consider temperature when evaluating its solubility characteristics.
  • pH Dependence: The acidic functional group (-COOH) can ionize depending on the pH of the solution, potentially increasing solubility in alkaline conditions.

Moreover, it can be noted that:

  1. The compound may exhibit limited water solubility due to hydrophobic interactions.
  2. In terms of practical applications, solubility plays a critical role in the formulation of pharmaceuticals.
  3. The presence of the methoxy group can enhance solubilization in certain organic solvents.

In conclusion, while 3-(6-methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid's solubility may not be universally high across all solvents, understanding its behavior in specific conditions is essential for effective application in chemical processes.

Interesting facts

Interesting Facts about 3-(6-Methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid

3-(6-Methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid is a fascinating compound in the realm of organic chemistry, particularly due to its unique structural attributes and applications in various fields. Here are some interesting aspects of this compound:

  • Structural Features: This compound features a naphthalene ring with a methoxy group, which enhances its hydrophobic character and can influence its biological activity.
  • Biological Interest: Compounds with similar structures have shown potential in pharmaceutical applications, particularly in the development of anti-inflammatory agents and other therapeutic uses.
  • Versatile Synthetic Pathways: The synthesis of this compound can involve multiple pathways, allowing chemists to explore various methodologies and techniques, including alkylation and aromatic substitution.
  • Environmental Implications: Understanding the behavior of such compounds in the environment is crucial, as they may have implications in ecological studies related to pollution and organic contaminants.
  • Research Potential: As a compound of interest, it can be a valuable subject for research in both medicinal chemistry and material science.

In summary, 3-(6-Methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid serves as a prime example of how intricate organic compounds can intersect with both scientific inquiry and practical applications. Its ability to bridge gaps between different fields highlights the importance of interdisciplinary approaches in modern chemistry.

Synonyms
METHALLENESTRIL
Methallenestrol
Novestrine
Vallestril
Ercostrol
Methallenoestril
517-18-0
Metalenestrilo
Methallenoestrolum
Methallenestril [INN]
Methallenestrilum
Metalenestrilo [Spanish]
Methallenestrilum [Latin]
Metalenestrilo [INN-Spanish]
Methallenestrilum [INN-Latin]
HSDB 3358
Methallenestril [INN:BAN]
EINECS 208-232-6
NSC-74235
3-(6-Methoxy-2-naphthyl)-2,2-dimethylpentanoic acid
XL025389JS
METHALLENESTRIL [MI]
3-(6-Methoxy-2-naphthyl)-2,2-dimethylvaleriansaeure
METHALLENESTRIL [HSDB]
METHALLENESTRIL [MART.]
DTXSID7023275
METHALLENESTRIL [WHO-DD]
3-(6-Methoxy-2-naphthyl)-3-ethyl-2,2-dimethylpropionsaeure
beta-(6-Methoxy-2-naphthyl)-alpha,alpha-dimethylvaleric acid
beta-Ethyl-6-methoxy-alpha,alpha-dimethyl-2-naphthalenepropionic acid
Methallenestrilum (Latin)
2-Naphthalenepropanoic acid, beta-ethyl-6-methoxy-alpha,alpha-dimethyl-
2-Naphthalenepropionic acid, beta-ethyl-6-methoxy-alpha,alpha-dimethyl-
Metalenestrilo (INN-Spanish)
Methallenestrilum (INN-Latin)
METHALLENESTRIL (MART.)
b-ethyl-6-methoxy-a,a-dimethyl-2-naphthalenepropionic acid
DTXCID803275
G03CB03
G03CC03
(3R)-3-(6-methoxynaphthalen-2-yl)-2,2-dimethylpentanoic acid
2-Naphthalenepropanoic acid, beta-ethyl-6-methoxy-alpha,alpha-dimethyl-(9CI)
208-232-6
3-(6-methoxynaphthalen-2-yl)-2,2-dimethylpentanoic acid
CHEBI:6808
2-Naphthalenepropanoic acid, beta-ethyl-6-methoxy-alpha,alpha-dimethyl- (9CI)
UNII-XL025389JS
15372-35-7
NCIOpen2_003939
SCHEMBL517936
CHEMBL1697842
2,2-dimethyl-3-[6-(methyloxy)naphthalen-2-yl]pentanoic acid
NSC74235
NSC81398
NSC81399
NSC-81398
NSC-81399
AKOS040753012
NS00032326
C07621
Q10843651
3-(6-methoxy-2-naphthyl)-2,2-dimethyl-pentanoic acid
.beta.-Ethyl-6-methoxy-.alpha.,.alpha.-dimethyl-2-naphthalenepropionic acid
2-Naphthalenepropanoic acid, .beta.-ethyl-6-methoxy-.alpha.,.alpha.-dimethyl-
2-Naphthalenepropionic acid, .beta.-ethyl-6-methoxy-.alpha.,.alpha.-dimethyl-