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Amitriptyline

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Identification
Molecular formula
C20H23N
CAS number
50-48-6
IUPAC name
3-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-propan-1-amine
State
State

At room temperature, amitriptyline is in a solid state.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
277.40g/mol
Molar mass
277.4030g/mol
Density
1.0284g/cm3
Appearence

Amitriptyline typically appears as a white to slightly yellowish crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 3-(6,11-dihydrobenzo b[1,4]benzodiazepin-5-yl)-N,N-dimethyl-propan-1-amine

The solubility of 3-(6,11-dihydrobenzo b[1,4]benzodiazepin-5-yl)-N,N-dimethyl-propan-1-amine is influenced by various factors that are intrinsic to its molecular structure. Understanding these solubility characteristics can be crucial for applications in pharmacology and formulation chemistry.

Key Factors Affecting Solubility:

  • Polarity: The compound exhibits both polar and non-polar characteristics due to the presence of amine groups and aromatic rings, which affects its solubility in different solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility in polar solvents, whereas lack of suitable interactions with nonpolar solvents may limit its solubility.
  • Molecular Weight: Higher molecular weight compounds often show lower solubility due to increased van der Waals forces, creating a significant impact on solubility compared to smaller molecules.

Analyzing the solubility of this compound reveals that:

  • It is likely to have limited solubility in water due to its hydrophobic aromatic structure.
  • It may be better soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), where its polar and non-polar components interact more favorably.

In conclusion, while general predictions can be made about the solubility of 3-(6,11-dihydrobenzo b[1,4]benzodiazepin-5-yl)-N,N-dimethyl-propan-1-amine, specific solubility data should be obtained experimentally for accurate formulation and therapeutic applications. As always, solubility is a key determinant in the efficacy of pharmaceutical compounds.

Interesting facts

Interesting Facts about 3-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-propan-1-amine

This intriguing compound belongs to a subclass of benzodiazepines, a group renowned for their psychoactive properties. Here are some fascinating insights that highlight its importance and potential uses in the field of chemistry and pharmacology:

  • Structure and Activity: The complex structure of this compound, with its unique fused ring system, enhances its interaction with neuroreceptors, particularly GABAA receptors, which play a pivotal role in inhibitory neurotransmission.
  • Pharmacological Potential: As a compound related to benzodiazepines, it could exhibit anxiolytic, sedative, and muscle relaxant properties. Researchers often investigate variants to develop safer and more effective alternatives to existing medications.
  • Research Interest: Compounds within its class can provide insights into neurological disorders, making them valuable in drug development for anxiety, depression, and sleep disorders. As stated by leading researchers, "The exploration of new derivatives is crucial for advancing treatment modalities."
  • Synthesis Challenges: The synthesis of such complex structures can be quite demanding, often requiring intricate multi-step processes. This highlights the innovation required in synthetic organic chemistry to create these molecules.
  • Safety and Regulation: Given the potential therapeutic effects accompanied by risks, such compounds undergo rigorous scrutiny and testing, emphasizing the need for responsible usage and comprehensive understanding.

The study of 3-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-propan-1-amine not only broadens our understanding of benzodiazepine chemistry but also illustrates the ongoing commitment of scientists to discover and optimize treatments for complex human conditions.

Synonyms
3RKH04FSV1
UNII-3RKH04FSV1
10-(3-Dimethylaminopropyl)-10,11-dihydro-(5H)-dibenzo-(b,E)(1,4)-diazepine
2204-57-1
10H-Dibenzo(b,E)(1,4)diazepine-10-propanamine, 5,11-dihydro-N,N-dimethyl-
5,11-Dihydro-N,N-dimethyl-10H-dibenzo(b,E)(1,4)diazepine-10-propanamine