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Amitriptyline

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Identification
Molecular formula
C20H23N
CAS number
50-48-6
IUPAC name
3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine
State
State

At room temperature, Amitriptyline is in a solid state, typically in the form of tablets for medical use.

Melting point (Celsius)
195.80
Melting point (Kelvin)
468.90
Boiling point (Celsius)
340.10
Boiling point (Kelvin)
613.20
General information
Molecular weight
277.40g/mol
Molar mass
277.4030g/mol
Density
1.0023g/cm3
Appearence

Amitriptyline is typically found as a white to off-white crystalline powder. It is practically odorless.

Comment on solubility

Solubility of 3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine

The solubility of 3-(6,11-dihydrobenzo[1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine is influenced by several factors, including its molecular structure and functional groups. Understanding its solubility characteristics is crucial for various applications, including pharmaceuticals and materials science. Here are some key points to consider:

  • Polarity: The presence of both hydrophobic aromatic rings and polar amine groups suggests a complex solubility profile. This compound may have limited solubility in water due to its non-polar regions.
  • Solvent Compatibility: It is likely to show better solubility in organic solvents such as ethanol, methanol, or dichloromethane, which can stabilize the hydrophobic interactions.
  • Temperature Influence: Solubility typically increases with temperature. Therefore, dissolving this compound at elevated temperatures could enhance its solubility in the chosen solvent.
  • pH Sensitivity: The solubility may vary with pH levels, particularly because amines can exist in protonated and unprotonated forms, influencing solubility in aqueous environments.

In summary, while 3-(6,11-dihydrobenzo[1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine is expected to exhibit minimal solubility in water, exploring various organic solvents and adjusting conditions such as temperature and pH could result in a more favorable dissolution process. Always keep in mind the importance of solvent choice and environmental conditions when determining solubility.

Interesting facts

Interesting Facts about 3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine

This compound, a fascinating member of the benzothiepin family, showcases the complexity and diversity of organic chemistry. Here are some intriguing aspects that highlight its significance:

  • Pharmaceutical Insight: Compounds like this one are often explored for their potential in the pharmaceutical industry. This specific structure could imply potential therapeutic applications, particularly in neurological or psychiatric treatments.
  • Structural Uniqueness: The presence of the benzo[c][1]benzothiepin moiety contributes to unique chemical properties, influencing how this compound interacts biologically. The intricate arrangement of sulfur and aromatic rings could affect its activity as a drug candidate.
  • Synthetic Pathways: The synthesis of such complex organic molecules often involves multiple steps, showcasing the creativity and precision required in organic synthesis. This highlights the importance of synthetic routes in preparing pharmaceutical agents.
  • Molecular Interactions: The amine group present can engage in hydrogen bonding, which might be critical for its interaction with biological receptors, altering its pharmacological profile.
  • Research Potential: As scientists delve deeper into its properties, there is potential for uncovering new therapeutic mechanisms that could pave the way for innovative treatments.

In the realm of organic chemistry and drug discovery, compounds like 3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine serve as invaluable tools for understanding complex biological systems. The ongoing research in this area could lead to groundbreaking advancements in medicine.

Synonyms
1886-45-9
3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethylpropan-1-amine
Hydrothiadene
Idrotiadene
6,11-Dihydro-N,N-dimethyldibenzo[b,e]thiepin-11-(1-propanamine)
BRN 1350072
d,l-11-(3-Dimethylaminopropyl)-6,11-dihydrodibenzo(b,d)thiepin
SCHEMBL13248563
DTXSID10940362
AKOS005066379
DIBENZO(b,e)THIEPIN-11-PROPYLAMINE, 6,11-DIHYDRO-N,N-DIMETHYL-
AE-641/00357061
11-(3-Dimethylaminopropyl)-6,11-dihydrodibenzo[b,e]thiepin
3-(6,11-dihydrodibenzo[b,e]thiepin-11-yl)-N,N-dimethylpropan-1-amine
N-[3-(6,11-dihydrodibenzo[b,e]thiepin-11-yl)propyl]-N,N-dimethylamine