Skip to main content

Clomipramine Hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C19H24ClN3S
CAS number
303-49-1
IUPAC name
3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium;chloride
State
State

At room temperature, clomipramine hydrochloride is typically in a solid state, existing as a crystalline powder. It is stable and non-volatile under normal conditions.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
351.94g/mol
Molar mass
351.9000g/mol
Density
1.2800g/cm3
Appearence

Clomipramine Hydrochloride typically appears as a white or slightly creamy crystalline powder. It is known for its fine and uniform crystalline structure.

Comment on solubility

Solubility of 3-(6,11-dihydrobenzo1benzothiepin-11-yl)propyl-dimethyl-ammonium;chloride

This compound presents interesting solubility characteristics, primarily influenced by its ammonium functional group and the presence of a chloride anion. Ammonium salts, such as this one, tend to exhibit high solubility in water due to their ionic nature. Here’s a breakdown of the factors affecting its solubility:

  • Hydrophilicity: The dimethylammonium group enhances the water solubility of the compound, allowing for better interaction with polar solvent molecules.
  • Hydrophobic Effects: Despite the hydrophilic nature brought by the ionic group, the presence of the 6,11-dihydrobenzo[c][1]benzothiepin moiety introduces a hydrophobic segment, which may impart a degree of insolubility in certain organic solvents.
  • Temperature Dependency: Like many salts, solubility may increase with rising temperatures, indicating a potential for greater dissolution at elevated conditions.
  • Solvent Impact: While the compound is expected to be soluble in polar solvents like water, its solubility in non-polar solvents may be significantly lower.

In summary, the solubility behavior of 3-(6,11-dihydrobenzo1benzothiepin-11-yl)propyl-dimethyl-ammonium;chloride is a fascinating interplay of ionic and hydrophobic forces, making it an intriguing subject for further investigation in various solvent systems. Understanding its solubility can pave the way for applications in pharmaceuticals, where the bioavailability of similar compounds is crucial.

Interesting facts

Interesting Facts about 3-(6,11-Dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium; Chloride

This fascinating compound stands out due to its unique structure and intriguing applications. Here are some compelling aspects worth noting:

  • Complex Structure: The core structure of this compound features a benzothiepin moiety, a rare scaffolding that provides distinctive properties essential for pharmaceuticals and organic chemistry.
  • Biological Activity: Compounds similar to this one have been investigated for their potential therapeutic effects. Researchers are particularly interested in their roles as antidepressants and in the treatment of various mental health disorders.
  • Quaternized Ammonium: The dimethylammonium portion indicates that this compound is a quaternary ammonium salt, which often exhibits surfactant properties and can enhance biological activity by improving solubility and membrane penetration.
  • Multifunctional Uses: Beyond its medicinal implications, such compounds have been explored in fields like material science and agriculture for their ability to act as growth regulators or herbicides.
  • Research and Development: With ongoing studies in medicinal chemistry, compounds like this continue to be synthesized and evaluated for their potential, opening doors for novel therapeutic agents.

In conclusion, the compound 3-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium; chloride serves as a prime example of how complex chemical structures can lead to significant findings in science. Its potential applications across various domains highlight the importance of continuing research in synthetic chemistry.

Synonyms
Hydrothiadene hydrochloride hemihydrate
846-54-8
6,11-Dihydro-N,N-dimethyldibenzo(b,e)thiepin-11-propylamine hydrochloride hydrate (2:2:1)
Dibenzo(b,e)thiepin-11-propylamine, 6,11-dihydro-N,N-dimethyl-, hydrochloride, hydrate (2:2:1)