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Gefitinib

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Identification
Molecular formula
C22H24ClFN4O3
CAS number
184475-35-2
IUPAC name
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
State
State

Gefitinib is a solid at room temperature. It is typically encountered as a powder in pharmaceutical formulations.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
773.15
Boiling point (Kelvin)
1 046.30
General information
Molecular weight
446.91g/mol
Molar mass
446.9060g/mol
Density
1.2000g/cm3
Appearence

Gefitinib typically appears as a white to slightly yellowish powder. It is an organic compound that can exist in its pure form as a crystalline solid.

Comment on solubility

Solubility of 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

The solubility of 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (C22H24ClFN4O3) can be influenced by various factors, including its chemical structure and environmental conditions. Here are some key aspects to consider regarding its solubility:

  • Polarity: Solubility is often dictated by the polarity of the compound. Compounds that are polar tend to dissolve well in polar solvents (like water), while nonpolar compounds prefer nonpolar solvents.
  • Functional Groups: The presence of functional groups, such as the amino and methoxy groups in this compound, can enhance its solubility in specific solvents. These groups can participate in hydrogen bonding, which can increase solubility in polar solvents.
  • pH Sensitivity: The solubility can also change with pH. Basic conditions might increase the ionization of the amino group, enhancing solubility in aqueous environments.

Some general rules of thumb for predicting solubility include:

  1. Like dissolves like: Polar solvents dissolve polar compounds and nonpolar solvents dissolve nonpolar compounds.
  2. Increase in temperature: Solubility often increases with temperature, particularly for solid solutes in liquid solvents.
  3. Additives: The presence of salts or other solutes can sometimes either enhance or inhibit the solubility of the compound.

In conclusion, while predicting the exact solubility of 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol without empirical data is challenging, understanding its chemical nature provides insight into its potential solubility characteristics.

Interesting facts

Interesting Facts about 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol is a fascinating compound in the field of medicinal chemistry, often studied for its potential therapeutic properties. Here are some notable points about this compound:

  • Quinazoline Backbone: The presence of the quinazoline moiety is significant as it is well-known for its diverse biological activities, including anticancer and antimicrobial properties.
  • Dimethoxy Groups: The two methoxy groups enhance the compound's lipophilicity, potentially improving its absorption and bioavailability in biological systems.
  • Potential Applications: Due to the arrangement of functional groups, this compound may have potential applications in the development of new drugs targeting various diseases, including cancer.
  • Research Opportunities: Scientists exploring structure-activity relationships (SAR) can benefit from studying this compound to design more effective analogs with improved efficacy and reduced side effects.
  • Mechanism of Action: While the exact mechanism of action requires further investigation, compounds like this one often interact with specific biological targets, making insights into its action critical for drug development.

The study of 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol represents just one example of how organic chemistry continues to innovate and contribute to medical advancements. As researchers delve deeper, they may uncover new pathways for therapeutic intervention, ensuring that compounds like this remain at the forefront of scientific inquiry.

In the world of chemistry, the potential of compounds is often just a research study away!

Synonyms
whi-p180
211555-08-7
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE
3-((6,7-Dimethoxyquinazolin-4-yl)amino)phenol
CHEMBL127907
3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol
WHI-P180, Hydrochloride
DTQ
JANEX 3
4-(3-Hydroxyanilino)-6,7-Dimethoxyquinazoline
3-(6,7-dimethoxyquinazolin-4-ylamino)phenol
4btk
MFCD02683970
1di8
Anilinoquinazoline deriv. 5
Phenol, 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-
WHI-P180(Janex 3)?
BDBM4622
SCHEMBL1180103
DTXSID50943478
BNDYIYYKEIXHNK-UHFFFAOYSA-N
HMS3229P15
BCP15153
EX-A3025
HSCI1_000392
s6520
AKOS002350928
CS-1702
DB03365
NCGC00379002-02
AC-35237
AS-35327
HY-15769
NS00069348
K00036
4-(3'-hydroxyanilino)-6,7-dimethoxyquinazoline
BRD-K82708110-003-01-5
Q27094307
WHI-P180; 4-(3'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, HCl