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Amitriptyline hydrochloride

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Identification
Molecular formula
C20H24ClN
CAS number
549-18-8
IUPAC name
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methyl-propan-1-amine;hydrochloride
State
State

At room temperature, amitriptyline hydrochloride is typically in a solid state. It is generally found in a crystalline or powder form and is processed into tablets for pharmaceutical use.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.00
Boiling point (Celsius)
292.30
Boiling point (Kelvin)
565.40
General information
Molecular weight
313.87g/mol
Molar mass
313.8670g/mol
Density
1.0906g/cm3
Appearence

Amitriptyline hydrochloride typically appears as a white or slightly yellow crystalline powder. It is hygroscopic, meaning it can absorb moisture from the air, and it is soluble in water. The crystalline powder may sometimes form into fine crystals when precipitated.

Comment on solubility

Solubility of 3-(6H-benzo[1]benzoxepin-11-ylidene)-N-methyl-propan-1-amine;hydrochloride

The solubility of this compound, known as 3-(6H-benzo[1]benzoxepin-11-ylidene)-N-methyl-propan-1-amine;hydrochloride, is influenced by its chemical structure and the presence of the hydrochloride moiety. Typically, hydrochloride salts exhibit notably improved solubility in water compared to their base counterparts. This is primarily due to the ionic nature of the salt.

Factors Influencing Solubility:

  • Protonation: The presence of the hydrochloride form suggests enhanced solubility due to protonation, which increases the compound's polarity.
  • Hydrophilicity: The structural features and functional groups within the compound can affect its hydrophilicity, impacting solubility in aqueous solutions.
  • Temperature: Like many compounds, solubility may increase with temperature; thus, higher temperatures can facilitate better dissolution.

In general, one can expect the compound's solubility to be relatively favorable in polar solvents, especially water, due to its hydrochloride form. Furthermore, exploratory studies or experimental evaluations are recommended to ascertain precise solubility parameters.

Overall, understanding the solubility characteristics of such compounds is crucial for their applications in pharmacology and medicinal chemistry, making this a pertinent area of investigation.

Interesting facts

Interesting Facts About 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methyl-propan-1-amine;hydrochloride

This fascinating compound, with its intricate structure, falls within the realm of organic chemistry and pharmacology. It is regarded for its notable pharmacological properties and has sparked interest in scientific research. Here are several interesting points about this compound:

  • Diverse Applications: This compound is often investigated for its potential applications in medicine, particularly in the area of mental health due to its psychoactive properties.
  • Complex Structure: The unique structural features of this compound, particularly the presence of the benzo[c][1]benzoxepin moiety, contribute to its intriguing chemical behavior and biological activity.
  • Research Importance: Ongoing research aims to better understand the mechanisms of action of this compound, which could lead to novel therapeutic strategies.
  • Potential Benefits: With a focus on neurochemistry, studies suggest that it may help in modulating neurotransmitter systems, making it a candidate for further investigation in treating various neurological disorders.

As noted in the words of a prominent chemist, "The true magic of chemistry lies in the ability to uncover the secrets within the molecular playground, and compounds like these are the keys to new discoveries." This compound exemplifies how intricate chemical structures have the potential to unlock new avenues in both research and application.

In summary, the exploration of 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methyl-propan-1-amine;hydrochloride not only enhances our understanding of organic chemistry but also pushes forward the boundaries of medical science.

Synonyms
Nor Doxepin Hydrochloride
2887-91-4
Desmethyldoxepine (hydrochloride)
Nordoxepin.HCl
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methylpropan-1-amine;hydrochloride
N-Desmethyldoxepin hydrochloride; Nordoxepin hydrochloride
SCHEMBL9181927
3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methylpropan-1-amine hydrochloride
GNPPEZGJRSOKRE-UHFFFAOYSA-N
GDC66554
ZEA69402
AKOS030254418
PD166180
H37072
Nordoxepin.HCl, 1mg/ml in Methanol (as free base)
methyl(3-{9-oxatricyclo[9.4.0.0(3),?]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amine hydrochloride