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Clomipramine Hydrochloride

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Identification
Molecular formula
C19H24ClN3O
CAS number
17321-77-6
IUPAC name
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine;hydrochloride
State
State

At room temperature, clomipramine hydrochloride is a solid, present as a crystalline powder. It remains stable under normal conditions of storage and handling.

Melting point (Celsius)
182.50
Melting point (Kelvin)
455.65
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
351.85g/mol
Molar mass
351.8450g/mol
Density
1.1926g/cm3
Appearence

Clomipramine hydrochloride appears as a white to off-white crystalline powder. It is odorless and slightly bitter in taste. The compound is very soluble in water and alcohol, providing clarity in solutions prepared for pharmaceutical uses.

Comment on solubility

Solubility of 3-(6H-benzo[1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine;hydrochloride

The solubility of the compound 3-(6H-benzo[1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine;hydrochloride can be somewhat complex to characterize due to its structural components. Here are some key points regarding its solubility:

  • Hydrochloride salt form: As a hydrochloride salt, this compound is generally expected to exhibit increased solubility in water compared to its free base form. The hydrochloride ions play a crucial role in enhancing solubility.
  • Polarity: The presence of polar functional groups can influence the solubility in aqueous solutions. Compounds that can form hydrogen bonds with water will typically dissolve more readily.
  • Solvents: Solubility may also vary depending on the solvent used. While this compound may be soluble in water, it is advisable to evaluate its solubility in organic solvents as well, such as ethanol or DMSO, to ascertain versatility in various chemical applications.
  • Temperature effect: It is important to note that solubility can change with temperature; typically, increasing temperature can enhance the solubility of many salts.
  • Practical testing: For precise applications, experimental determination of solubility in various solvents at different temperatures is recommended to achieve the desired concentration and effectiveness in usage.

In summary, while the hydrochloride form suggests *enhanced solubility*, the actual solubility is contingent upon several factors, including solvent choice, temperature, and the specific interactions of the compound in solution. Always consider conducting detailed solubility tests to obtain quantitative data.

Interesting facts

Interesting Facts about 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine;hydrochloride

This compound, known as 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine;hydrochloride, is a fascinating entity in the world of organic chemistry. Its elaborate structure and unique properties make it a subject of interest for researchers.

Key Highlights:

  • Diverse Applications: Compounds like this one are often investigated for their potential therapeutic uses, particularly in the fields of medicinal chemistry and pharmacology.
  • Chemical Structure: The benzo and benzoxepin components suggest interesting interactions with biological targets, which can lead to novel medicinal applications.
  • Role as a Ligand: Its amine group may facilitate interactions within biological systems, acting as a ligand in various chemical reactions.
  • Modification Potential: The presence of dimethyl groups enhances the compound's lipophilicity, allowing chemists to explore modifications that can alter its pharmacokinetic properties.

Scientific Significance:

As a hydrogen chloride salt, this compound benefits from increased stability and solubility in various solvents, making it easier to study in laboratory settings. Currently, research is being conducted on similar compounds to explore:

  • Neurochemical pathways and their implications in treating mental health disorders.
  • Effects on receptor binding, which can help in designing new drugs with enhanced efficacy.
  • Potential anti-cancer properties, given the complex aromatic nature of its structure.

In conclusion, 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine;hydrochloride embodies the elegance of organic synthesis and offers an exciting area of exploration for scientists and students alike. Its intricate molecular architecture not only provides insight into biochemical interactions but also paves the way for advanced research and potential breakthroughs in medicinal chemistry.

Synonyms
Doxepin-d3 Hydrochloride
Sinequan
Doxepin D3 HCl
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
NSC-108160
(Z)-DoxepinHydrochloride
347840-07-7
Doxepin hydrochloride (mixture of isomers)
SCHEMBL41532
CHEMBL1628234
1-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1)
BCP28507
BCP33258
dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine hydrochloride
AKOS030241370
H11374
11-(3-dimethylaminopropylidene)-6h-dibenz[b,e]oxepin hydrochloride
dimethyl(3-{9-oxatricyclo[9.4.0.0(3),?]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amine hydrochloride