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Brotizolam

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Identification
Molecular formula
C18H15BrCl2N4O
CAS number
57801-81-7
IUPAC name
3-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium;dichloride
State
State

At room temperature, brotizolam is solid. It is typically distributed in tablet form for pharmaceutical use.

Melting point (Celsius)
274.00
Melting point (Kelvin)
547.00
Boiling point (Celsius)
406.20
Boiling point (Kelvin)
679.20
General information
Molecular weight
418.76g/mol
Molar mass
418.7640g/mol
Density
1.3000g/cm3
Appearence

Brotizolam commonly appears as a crystalline solid. Its color can range from off-white to pale yellow.

Comment on solubility

Solubility of 3-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium; dichloride

The solubility of 3-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium; dichloride can be influenced by various factors, including temperature, solvent type, and the presence of other solutes. In general, this compound is expected to exhibit the following solubility characteristics:

  • Water Solubility: Given that this compound contains a quaternary ammonium structure, it is likely to be soluble in polar solvents, especially water, due to its ionic nature.
  • Organic Solvents: It may have limited solubility in non-polar organic solvents due to its polar nature; hence, solvents like acetone or alcohols might be more favorable.
  • Temperature Dependence: As with many compounds, the solubility may increase with temperature, making it crucial to consider when preparing solutions.

Chemical compounds with similar structures often hint at their solubility behavior. As a general observation:

  1. Ionic compounds, like this one, tend to be more soluble in water.
  2. Hydrophobic interactions can limit solubility in non-polar environments.

Understanding the solubility of this compound is essential for applications in various chemical processes and potential pharmaceutical usages. As the adage goes, “like dissolves like,” so recognizing the nature of both the solute and solvent is vital for effective solution preparation.

Interesting facts

Interesting Facts about 3-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium;dichloride

This compound belongs to a class of substances that are structurally related to benzodiazepines, which are known for their pharmacological effects on the central nervous system. Here are some intriguing aspects of this chemical:

  • Pharmacological Potential: Compounds like this one can exhibit properties similar to traditional benzodiazepines, including anxiolytic and muscle relaxant effects. Researchers are continually investigating their applications in medicine.
  • Complex Structure: The incorporation of a bromine atom and a pyridine ring in its structure can significantly influence its reactivity and interactions with biological targets, enhancing its efficacy and selectivity.
  • Positive Charge: The presence of a quaternary ammonium group may confer unique properties such as enhanced solubility in biological fluids, which is essential for effective drug delivery.
  • Synthetic Versatility: The synthesis of this compound showcases the versatility of organic chemistry, as it involves multiple steps for the assembly of complex molecular features.
  • Applications in Research: This compound provides insights into the development of new therapeutic agents, furthering the study of neuropharmacology and potentially leading to innovative treatments for various neurological disorders.

As scientists continue to unravel the mechanisms behind such compounds, they contribute to the broader understanding of drug design and action, paving the way for future advancements in healthcare.

Synonyms
4466-96-0
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-1-(3-(dimethylamino)propyl)-5-(2-pyridyl)-, dihydrochloride
7-Bromo-1-(3-(dimethylamino)propyl)-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one 2HCl