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Tacrine hydrochloride

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Identification
Molecular formula
C17H26Cl3N3
CAS number
1684-40-8
IUPAC name
3-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)ammonio]propyl-diethyl-ammonium;dichloride
State
State

At room temperature, Tacrine hydrochloride is in a solid state, characterized by its crystalline powder form as described in its appearance.

Melting point (Celsius)
248.00
Melting point (Kelvin)
521.15
Boiling point (Celsius)
363.00
Boiling point (Kelvin)
636.15
General information
Molecular weight
398.87g/mol
Molar mass
398.8700g/mol
Density
1.1700g/cm3
Appearence

Tacrine hydrochloride typically appears as an off-white to light beige crystalline powder. The substance is highly soluble in water but less so in organic solvents.

Comment on solubility

Solubility of 3-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)ammonio]propyl-diethyl-ammonium; dichloride

The solubility of 3-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)ammonio]propyl-diethyl-ammonium dichloride can be influenced by various factors due to its complex structure. This compound features a quaternary ammonium salt, which generally provides some insights into its solubility behavior:

  • Polar Nature: Being an ammonium salt, it is likely to be soluble in polar solvents, particularly water, because ammonium compounds typically exhibit ionic characteristics.
  • Hydrophobic Interactions: The presence of the tetrahydroacridine moiety may introduce some hydrophobic interactions, potentially affecting the overall solubility.
  • pH Dependence: The solubility can also vary with pH. In acidic conditions, the compound may remain protonated, increasing its solubility.
  • Temperature Influence: Like many salts, solubility may increase with temperature, allowing for the dissolution of a larger quantity in a given volume of solvent.

Overall, while the amphipathic character of the compound suggests solubility in water, additional experimental data would provide a clearer picture of its solubility under specific conditions. As always, consulting the solubility data from empirical studies is essential for accurate applications in various fields.

Interesting facts

Interesting Facts about 3-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)ammonio]propyl-diethyl-ammonium; dichloride

This fascinating compound belongs to a class of chemicals known for their potential applications in medicinal chemistry, particularly in the realm of neuropharmacology. Its unique structure is characterized by a central ammonium group, making it a cationic species. Here's why this compound captures the interest of chemists and pharmacologists alike:

  • Pharmacological Potential: The 7-chloro-1,2,3,4-tetrahydroacridine moiety is significant because it's a derivative of acridine, a structure related to several pharmacologically active compounds. This suggests potential uses in therapies for neurological disorders.
  • Dual Action: The presence of both ammonium and diethylammonium groups may allow this compound to interact with different biological pathways, enhancing the likelihood of it exhibiting multifaceted actions against disease.
  • Formulation Applications: The dichloride form indicates that this compound may be utilized in various formulations, possibly affecting its solubility and bioavailability, which are critical in drug delivery and efficacy.
  • Research Interest: Scientists are consistently exploring the relationship between acridine derivatives and their effects on diseases such as Alzheimer's, given that compounds with similar structures have shown promise in enhancing cognitive functions.

As noted by one researcher, "Understanding the intricacies of such compounds can lead to breakthroughs in therapies that are tailored to combat complex neurological conditions."

In summary, 3-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)ammonio]propyl-diethyl-ammonium; dichloride is not just a chemical entity; it represents a crucial intersection between chemistry and therapeutic advancement. Its composition promises rich avenues for investigation, making it an exciting subject for study in medicinal chemistry.

Synonyms
NSC 2461
Acridine, 1,2,3,4-tetrahydro-7-chloro-9-(3-(diethylamino)propylamino)-, dihydrochloride
1,3-Propanediamine, N'-(7-chloro-1,2,3,4-tetrahydro-9-acridinyl)-N,N-diethyl-, dihydrochloride
7-Chloro-9-(3-(diethylamino)propylamino)-1,2,3,4-tetrahydroacridine dihydrochloride
5393-97-5
1,3-Propanediamine, N'-(7-chloro-1,2,3,4-tetrahydro-9-acridinyl)-N,N-diethyl-, dihydrochloride (9CI)