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Midazolam

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Identification
Molecular formula
C18H14ClFN3O3
CAS number
59467-70-8
IUPAC name
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-diethyl-ammonium;dichloride
State
State

At room temperature, Midazolam is typically found as a solid in its powder form. It can also be dissolved in a liquid to form an injectable solution that is clear and colorless.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
362.24g/mol
Molar mass
362.2440g/mol
Density
1.2000g/cm3
Appearence

Midazolam typically appears as a white or off-white powder when it is in its pure form. It may also be available in solution form, which is clear and colorless. The powder is typically very fine and crystalline.

Comment on solubility

Solubility of 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-diethyl-ammonium; dichloride

The solubility of this compound is influenced by various factors due to its complex structure. Consider the following aspects:

  • Ionic Nature: The presence of the diethyl-ammonium group indicates that this compound is likely to be ionic in nature. Ionic compounds typically have higher solubility in polar solvents, such as water.
  • Chloride Counterions: The dichloride component can enhance the solubility in aqueous solutions due to the dissociation of chloride ions, which are highly soluble.
  • Substituents: The presence of fluorophenyl and chloro substituents on the benzodiazepine ring may impact the solubility further. Halogen groups generally impart unique interactions that can either hinder or promote solubility.

In summary, while ionic compounds are generally soluble in water, the overall solubility of this particular compound would need to be assessed experimentally, taking into account the influence of all substituents and structural features. It could exhibit high solubility in polar solvents while showing reduced solubility in non-polar solvents due to its complex structural characteristics.

Interesting facts

Interesting Facts About 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-diethyl-ammonium;dichloride

This compound is a remarkable example of a modified benzodiazepine, notable for its intricate structure and potential pharmacological applications. As part of the benzodiazepine class, it exhibits distinct properties that can significantly influence its interaction with biological systems.

Key Features

  • Pharmacological Relevance: Benzodiazepines are well-known for their anxiolytic, sedative, and muscle relaxant properties. This compound’s unique modifications may enhance its affinity for specific receptors.
  • Chlorine and Fluorine Substituents: The presence of chlorine and fluorine atoms often leads to increased lipophilicity, potentially improving the compound's ability to cross the blood-brain barrier. This could significantly affect its efficacy and side-effects.
  • Ammonium Salt Form: The dichloride form indicates the compound is a quaternary ammonium salt, which can impart solubility benefits and modify how the compound interacts with the body compared to uncharged counterparts.
  • Structural Insights: With its dihydro-benzodiazepine core, this compound underscores how structural variations among compounds in the same class can impart unique biological activities.

Interesting Applications

This compound, like other benzodiazepines, holds promise for various therapeutic applications:

  • Treatment of anxiety disorders
  • Potential role in managing sleep disturbances
  • Exploration for neuroprotective effects

In conclusion, the complex architecture and functional modifications of 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-diethyl-ammonium;dichloride present a fascinating case study. As researchers delve deeper into its characteristics, this compound may reveal even more about the intricate relationship between molecular structure and biological function.

Synonyms
4084-17-7
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(3-(diethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride