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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-61-3
IUPAC name
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium;dichloride
State
State
At room temperature, clonazepam is in a solid state, typically in the form of a crystalline powder. It is stable under normal conditions but should be stored properly to maintain its integrity.
Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
298.15
Boiling point (Kelvin)
571.30
General information
Molecular weight
315.72g/mol
Molar mass
315.7150g/mol
Density
1.4200g/cm3
Appearence
Clonazepam typically appears as a white to light yellow crystalline powder. The compound is known to be nearly odorless and has a characteristic bitter taste.
Comment on solubility

Solubility of 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium;dichloride

This compound, due to its complex structure, exhibits intermediate to high solubility in various solvents. Its solubility profile can be described with the following key considerations:

  • Polarity: The presence of the quaternary ammonium group enhances its solubility in polar solvents, particularly water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly increase solubility in compatible solvents.
  • Solvent Effects: The solubility may vary considerably depending on the solvent used. For instance, it is expected to be more soluble in dimethyl sulfoxide (DMSO) and less so in non-polar solvents like hexane.
  • Temperature Influence: Increasing temperature tends to enhance solubility, allowing for a greater dissolution of the compound in solvent.

In summary, while the compound showcases favorable solubility characteristics in polar environments, understanding these dynamics is crucial for its effective application in various chemical contexts.

Interesting facts

Interesting Facts about 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium; dichloride

This fascinating compound is part of the larger family of benzodiazepines, which are widely known for their therapeutic applications, primarily as anxiolytics, sedatives, and muscle relaxants. The incorporation of the benzodiazepine structure lends pharmacological activity that is of great interest in medicinal chemistry.

Key Features:

  • Chlorine and Fluorine Substitution: The presence of chlorine and fluorine atoms enhances the lipophilicity of the compound, potentially improving its ability to cross biological membranes and thus interacting more effectively with its target sites.
  • Dimethylammonium Group: This ammonium moiety may confer unique properties to the compound, including increased solubility in biological systems and interactions with various receptors.
  • Potential Therapeutic Uses: Given its structure, this compound may exhibit potential applications in treating anxiety disorders or sleep disturbances, with ongoing research dedicated to elucidating its full effects.

Furthermore, the compound’s structural complexity offers a rich avenue for pharmacological studies. Research within the field often quotes, "The more nuanced the structure, the greater the potential for discovery." Consequently, this compound not only showcases the intricate nature of organic synthesis but also exemplifies how subtle changes in chemical structure can yield significant variations in biological activity.

In conclusion, 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-dimethyl-ammonium; dichloride stands as a compelling subject in the realm of medicinal chemistry, inviting further research to unravel its complexities and harness its potential benefits.

Synonyms
4084-16-6
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(3-(dimethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride