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Diazepam

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Identification
Molecular formula
C20H19Cl2FN3O2
CAS number
439-14-5
IUPAC name
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-methyl-ammonium;dichloride
State
State

At room temperature, diazepam is typically in a solid crystalline state. It is not very soluble in water, which affects its applications in solution forms. In solid form, it is stable under standard conditions but needs protection from light and moisture.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
377.20
Boiling point (Kelvin)
650.35
General information
Molecular weight
703.18g/mol
Molar mass
703.1770g/mol
Density
1.3060g/cm3
Appearence

Diazepam is a yellowish, crystalline compound. It can also appear as a fine powder. In some formulations, it may have a slightly off-white to yellow hue. The compound is sensitive to light, and prolonged exposure can cause discoloration. It has minimal odor.

Comment on solubility

Solubility of 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-methyl-ammonium; dichloride

The solubility of 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-methyl-ammonium; dichloride is influenced by several factors. This compound, characterized by its specialized structure, exhibits the following solubility traits:

  • Solvent Dependence: Generally, compounds with quaternary ammonium groups like this one tend to be more soluble in polar solvents such as water due to their ionic nature.
  • Ionic Character: As this compound is a dichloride salt, the presence of chloride ions increases its solubility in aqueous solutions.
  • Temperature Influence: Like many salts, the solubility may increase with temperature, making it more pronounced in warmer conditions.

The overall solubility of this compound can be summarized as moderate to high in polar solvents, particularly water. However, it may show limited solubility in non-polar solvents due to the lack of suitable interactions.

In summary, one might say that "solubility is the key to the door of chemical reactivity," making it essential to consider when working with 3-[7-chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-methyl-ammonium; dichloride in various applications.

Interesting facts

Interesting Facts about 3-[7-Chloro-5-(2-fluorophenyl)-2-oxo-4,5-dihydro-3H-1,4-benzodiazepin-4-ium-1-yl]propyl-methyl-ammonium Dichloride

This compound, often referred to by its shorter name in the field, is part of a fascinating class of compounds known as benzodiazepines. Here are some noteworthy aspects:

  • Therapeutic Applications: Benzodiazepines are widely recognized for their use in medicine, particularly for their anxiolytic, sedative, and muscle relaxant properties. This specific compound is being researched for potential benefits in treating anxiety disorders.
  • Structure-Activity Relationship: The presence of the chlorine and fluorine substituents in the benzodiazepine structure can significantly influence its activity and pharmacokinetics. This highlights the importance of structure in determining the compound's effectiveness as a therapeutic agent.
  • Ionization and Solubility: As a quaternary ammonium compound, it is expected to have interesting ionization properties that can affect its solubility and interactions in biological systems. This aspect plays a crucial role in how the compound is absorbed and utilized in the body.
  • Pharmacodynamics: Research into this compound sheds light on its mode of action on the GABAA receptors, essential for understanding how it induces sedation and relaxation, which is a crucial aspect of benzodiazepine pharmacology.
  • Combination Therapy: Investigations into the use of this compound with other therapeutic agents are ongoing, which could lead to synergistic effects in the treatment of various psychiatric conditions.

Overall, this compound exemplifies the intricate balance of chemistry and pharmacology, demonstrating how structural nuances can lead to significant changes in biological function and therapeutic applications. As the scientific community continues to explore its potential, it reinforces the profound impact that chemical research can have on modern medicine.

Synonyms
4191-05-3
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-(o-fluorophenyl)-1-(3-(methylamino)propyl)-, dihydrochloride, hydrate