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Estradiol phenylpropionate

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Identification
Molecular formula
C28H36O3
CAS number
50-50-0
IUPAC name
3-[(8R,9S,13S,14S,17S)-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]prop-2-ynyl 3-phenylpropanoate
State
State

At room temperature, Estradiol phenylpropionate is in a solid state, appearing as white or nearly white crystalline powder.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.20
Boiling point (Celsius)
413.20
Boiling point (Kelvin)
686.30
General information
Molecular weight
450.62g/mol
Molar mass
450.6190g/mol
Density
1.1800g/cm3
Appearence

Estradiol phenylpropionate is a white to creamy white crystalline powder. It is often formulated into oily solutions for injection due to its poor solubility in water.

Comment on solubility

Solubility of 3-[(8R,9S,13S,14S,17S)-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]prop-2-ynyl 3-phenylpropanoate

The solubility of the compound 3-[(8R,9S,13S,14S,17S)-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]prop-2-ynyl 3-phenylpropanoate is influenced by several factors, primarily due to its complex structure and the presence of various functional groups. Understanding these solubility characteristics is crucial for its applications. Consider the following aspects of its solubility:

  • Polarity: The presence of hydroxyl (-OH) and methoxy (-OCH3) groups suggests a degree of polarity, which typically enhances solubility in polar solvents such as water and alcohols.
  • Hydrophobic regions: The extensive hydrocarbon framework may create hydrophobic areas that can hinder solubility in highly polar solvents, promoting better solubility in non-polar solvents like chloroform or hexane.
  • Temperature influence: Solubility is often temperature-dependent; increasing temperature can enhance the solubility of organic compounds in solvents.

In summary, the solubility behavior of this compound can be described as complex, as it may exhibit varying solubility properties depending on the conditions and solvents used. It is essential to conduct experimental solubility tests to determine the specific solubility limits in various solvents.

Interesting facts

Interesting Facts about 3-[(8R,9S,13S,14S,17S)-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]prop-2-ynyl 3-phenylpropanoate

This fascinating compound belongs to a class of molecules that often serve significant roles in biological systems and medicinal chemistry. It is primarily noted for its potential applications in therapeutic contexts, particularly related to hormone-like activity. Below are some key points that encapsulate the essence of this compound:

  • Complex Structure: The compound features a multi-ring structure that is characteristic of many steroid hormones, granting it unique properties and biological activity.
  • Potential Therapeutic Uses: Due to its structural similarities to certain hormones, the compound is being studied for its ability to interact with hormone receptors, which could lead to new treatments for hormone-related conditions.
  • Stereochemistry: The stereochemical configuration, designated by the R and S designations, indicates the specific three-dimensional arrangement of atoms that can greatly influence the compound’s biological activity.
  • Natural Products: Many compounds with similar frameworks are derived from natural products, which makes this compound an intriguing subject for research into bioactive substances found in nature.
  • Analytical Interest: Researchers utilize various analytical techniques, such as NMR spectroscopy and mass spectrometry, to study the compound’s properties and interactions, furthering our understanding of complex organic molecules.

As such, the study of 3-[(8R,9S,13S,14S,17S)-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]prop-2-ynyl 3-phenylpropanoate represents a remarkable intersection of synthetic and natural chemistry, paving the way for innovations in the fields of pharmacology and medicinal chemistry. Scientists are continually excited by the possibilities that such complex molecules present, as they may unlock new avenues for treatment and understanding of various biological processes.