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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid
State
State

At room temperature, Iopamidol is a solid. It usually exists in the form of a powder and is stable under ambient conditions. Its specific structure, characterized by the presence of iodine atoms, is deliberately designed for its application as a radiopaque agent in diagnostic imaging.

Melting point (Celsius)
265.00
Melting point (Kelvin)
538.15
Boiling point (Celsius)
150.00
Boiling point (Kelvin)
423.15
General information
Molecular weight
777.09g/mol
Molar mass
777.0910g/mol
Density
2.3500g/cm3
Appearence

Iopamidol appears as a white or almost white crystalline powder. It is typically odorless and stable under normal conditions of storage and handling. This compound is recognized by its distinctive structural composition due to the presence of iodine atoms, giving it significant density and opacity, crucial for its use in medical imaging.

Comment on solubility

Solubility of 3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid

3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid exhibits interesting solubility characteristics, which can be highlighted as follows:

  • Polar Nature: Due to the presence of functional groups such as acetamido and hydroxyethylcarbamoyl, this compound is likely to be polar, which generally enhances its solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyethyl and acetamido groups can participate in hydrogen bonding, a crucial factor that promotes solubility in aqueous environments.
  • Iodinated Structure: The presence of multiple iodine atoms contributes to hydrophobic characteristics. However, the overall influence of the polar functional groups may still permit a reasonable level of solubility.
  • Temperature Influence: Solubility often increases with temperature, suggesting that raising the temperature may enhance the dissolution of this compound in suitable solvents.

Overall, while the presence of iodine might introduce some challenges regarding solubility, the polar functional groups could provide adequate solubility in various solvents, making it potentially useful in certain applications. As always, specific solubility data should be obtained through experimental characterization for definitive insights.

Interesting facts

Interesting Facts about 3-Acetamido-5-(2-Hydroxyethylcarbamoyl)-2,4,6-Triiodo-Benzoic Acid

3-Acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid is a fascinating compound, especially known for its role as a contrast agent in medical imaging, notably in Computed Tomography (CT) scans. Below are some intriguing aspects of this compound:

  • Medical Applications: One of the primary uses of this compound is in its capacity to enhance the visibility of specific internal structures during imaging procedures. This is critical for accurate diagnostics.
  • Unique Structure: It features multiple iodine atoms, which provide high radiopacity, making it an effective imaging agent.
  • Biodistribution: The compound is designed to localize in specific tissues, which can help in identifying pathological tissues from normal ones in a non-invasive manner.
  • Design Purpose: The incorporation of functional groups, such as acetamido and hydroxyethylcarbamoyl, enhances solubility and biological compatibility, improving patient safety and imaging quality.
  • Research Potential: Ongoing studies may reveal even more uses in targeted drug delivery systems or novel therapeutic approaches by modifying its structure.

In summary, 3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid is not only essential in medical imaging but also represents a great example of the intersection between chemistry and medicine. As research progresses, the potential applications for this compound may continue to expand, echoing the importance of chemical innovation in healthcare.

Synonyms
Ioxitalamic acid
28179-44-4
Acido ioxitalamico
Acide ioxitalamique
Acidum ioxitalamicum
Ioxithalamic acid
AG 58107
3-Acetamido-5-((2-hydroxyethyl)carbamoyl)-2,4,6-triiodobenzoic acid
967RDI7Z6K
AG-58107
DTXSID60182457
5-Acetamido-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid
3-(Acetylamino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodobenzoic acid
3-(Acetylamino)-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodobenzoic Acid
3-(Acetylamino)-5-{[(2-hydroxyethyl)amino]carbonyl}-2,4,6-triiodobenzoic acid
3-Acetamido-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid
RefChem:148614
DTXCID70104948
V08AA05
248-887-5
iooxitalamic acid
3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid
CHEBI:83517
Ioxitalamic acid (INN)
IOXITALAMIC ACID [INN]
3-(Acetamido)-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodo-benzoic acid
Acido iossitalamico
Acidum joxitalamicum
Acido iossitalamico [DCIT]
UNII-967RDI7Z6K
Ioxitalamic acid [INN:DCF]
Acide ioxitalamique [INN-French]
Acido ioxitalamico [INN-Spanish]
Acidum ioxitalamicum [INN-Latin]
C12H11I3N2O5
EINECS 248-887-5
MFCD00867942
ioxitalamic acid sodium salt
MLS006010884
SCHEMBL455411
Acido ioxitalamico;Ioxitalamate
orb1306870
CHEMBL2107239
SCHEMBL29815239
IOXITALAMIC ACID [MART.]
IOXITALAMIC ACID [WHO-DD]
BCP34384
3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid
AKOS016010458
DB13444
SMR004701800
TS-08080
HY-125695
CS-0093036
NS00000290
D07418
F20665
179I444
EN300-18568452
SR-01000945067
Q3604532
SR-01000945067-1
5-acetamido-2,4,6-triiodo-N-(2-hydroxyethyl)-isophthalamic acid
3-(acetylamino)-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid
3-Acetamido-2,4,6-triiodo-(N-beta-hydroxyethyl)isophthalic Acid Monoamide