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Iohexol

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Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid;6-(methylamino)hexane-1,2,3,4,5-pentol
State
State

At room temperature, iohexol is typically a solid in the form of a crystalline powder. When prepared for medical applications, it is used as a solution due to its excellent solubility in water, forming a clear liquid that is easily administered as a contrast agent.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.00
Boiling point (Celsius)
675.00
Boiling point (Kelvin)
948.00
General information
Molecular weight
821.14g/mol
Molar mass
821.1350g/mol
Density
1.4000g/cm3
Appearence

Iohexol appears as a white or almost white crystalline powder. It is hygroscopic, meaning it tends to absorb moisture from the environment. Due to its nature as a contrast medium, in practical applications, it often appears as a clear, colorless to slightly yellow solution when dissolved for use in medical imaging procedures.

Comment on solubility

Solubility of 3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid; 6-(methylamino)hexane-1,2,3,4,5-pentol

The solubility profile of such a complex compound can be quite intriguing. Here, we delve into the solubility characteristics that may influence its behavior in various environments:

  • Polarity: The presence of both hydrophilic functional groups (like –OH and –NH groups) and hydrophobic regions suggests that the compound may show variable solubility in different solvents.
  • Aqueous Solubility: Due to the hydroxyl groups, this compound is likely to have decent solubility in water, especially if the concentration of polar groups is high enough to overcome the steric hindrance associated with the bulky iodine atoms.
  • Organic Solvents: It may exhibit better solubility in organic solvents, such as alcohols or dimethyl sulfoxide (DMSO), where the hydrophobic regions can interact favorably.
  • Effect of Iodine: The three iodine atoms incorporated can add to the hydrophobic character, potentially affecting solubility: their presence may hinder solvation in aqueous environments.
  • Temperature Influence: Like many compounds, solubility may increase with rising temperatures; thus, analyzing it under varied thermal conditions will yield more information.

In summary, while the intricate nature of 3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic acid; 6-(methylamino)hexane-1,2,3,4,5-pentol suggests a complex solubility behavior, understanding both structural aspects and environmental factors is crucial for predicting its solvation. Careful experimentation will clarify its solubility in different mediums.

Interesting facts

Exploring 3-Acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-benzoic Acid

This fascinating compound is known for its unique structural features and potential applications in various scientific fields. Here are some interesting facts about it:

  • Health Applications: The presence of iodine in its structure makes it a compound of interest in medical imaging, notably in X-ray contrast agents, as iodine can enhance contrast in imaging techniques.
  • Biological Activity: Its acetamido and hydroxyethylcarbamoyl groups suggest that this compound may exhibit biological activities, potentially being studied for pharmaceutical applications such as drug formulation.
  • Novel Synthesis: Chemists are continually exploring synthetic pathways to create such compounds, incorporating different functional groups to enhance efficacy and reduce toxicity.

"Chemistry is the building block of life," and compounds like this one exemplify how specific molecular configurations can lead to significant practical applications.

Exploring 6-(Methylamino)hexane-1,2,3,4,5-pentol

This compound is characterized by its complex polyol structure, offering a range of chemical properties and potential applications. Below are some key points of interest:

  • Polyol Characteristics: The presence of multiple hydroxyl (-OH) groups contributes to the compound's potential use in the development of biodegradable polymers and drug delivery systems.
  • Biochemical Relevance: Its methylamino group can enhance the solubility and bioavailability of drugs, making it relevant in medicinal chemistry.
  • Versatile Reactions: The hydroxyl groups allow for numerous derivatization reactions, giving chemists flexibility in modifying the compound for specific applications.

In the world of chemical science, these intricate compounds serve as a reminder of the complexity and beauty of molecular interactions. Understanding and manipulating these structures can lead to groundbreaking innovations in medicine and technology.

Synonyms
3-[(1-Hydroxyethylidene)amino]-5-{hydroxy[(2-hydroxyethyl)imino]methyl}-2,4,6-triiodobenzoic acid--1-deoxy-1-(methylamino)hexitol (1/1)