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Iopamic Acid

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Identification
Molecular formula
C14H13I3N2O4
CAS number
31112-62-6
IUPAC name
3-acetamido-5-(acetamidomethyl)-2,4,6-triiodo-benzoic acid
State
State

Iopamic acid is a solid at room temperature, commonly available in a powder form. It is non-volatile and remains stable under normal conditions.

Melting point (Celsius)
237.00
Melting point (Kelvin)
510.00
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.00
General information
Molecular weight
613.95g/mol
Molar mass
613.9510g/mol
Density
2.4710g/cm3
Appearence

Iopamic acid is typically a white to off-white powder. It is crystalline in nature, reflecting its solid state at room temperature.

Comment on solubility

Solubility of 3-acetamido-5-(acetamidomethyl)-2,4,6-triiodo-benzoic acid

The solubility of the compound 3-acetamido-5-(acetamidomethyl)-2,4,6-triiodo-benzoic acid (C14H13I3N2O4) can be influenced by various factors, primarily the presence of iodine atoms in the molecule. Due to its unique structure, the solubility characteristics are notable:

  • Polar and Nonpolar Interactions: While the acetamido groups contribute to polar interactions, the presence of trihalogenated iodines can lead to *lower solubility* in water.
  • pH Sensitivity: The solubility of this compound may vary with pH, as benzoic acids typically exhibit increased solubility in a more alkaline environment.
  • Solvent Compatibility: It is likely to be more soluble in organic solvents, such as dimethyl sulfoxide (DMSO) or dimethylformamide (DMF), compared to polar solvents like water.

In summary, the solubility of 3-acetamido-5-(acetamidomethyl)-2,4,6-triiodo-benzoic acid is a complex interplay between its polar and nonpolar characteristics, influenced significantly by environmental factors. Understanding these aspects can help in determining optimal conditions for its application in various chemical processes.

Interesting facts

Interesting Facts about 3-acetamido-5-(acetamidomethyl)-2,4,6-triiodo-benzoic acid

This fascinating compound, 3-acetamido-5-(acetamidomethyl)-2,4,6-triiodo-benzoic acid, is part of a class of chemicals known for their significant roles in medicinal chemistry and imaging applications. Here are some captivating aspects:

  • Functional Groups: The compound features both acetamido and triiodo substituents, showcasing its complex structure that combines various chemical functionalities. This diversity enhances its potential applications in pharmaceuticals.
  • Medical Relevance: Triiodobenzene derivatives like this compound have been researched for their potential use in imaging techniques, particularly in the field of nuclear medicine, where they aid in the visualization of physiological processes.
  • Radiopharmaceuticals: Due to the presence of iodine, which has several isotopes suitable for imaging, this compound may play a role in the development of radio-labeled drugs, contributing significantly to diagnostic procedures.
  • Synthesis Insights: The synthesis of such compounds often involves strategic manipulation of the aromatic ring to introduce iodine and acetamido groups, demonstrating a blend of organic synthesis techniques and reaction conditions.
  • Structure Activity Relationship: Understanding how variations in the structure of this compound affect its biological activity can lead to the discovery of new therapeutic agents, illustrating the importance of chemical modification in drug development.

This compound not only exemplifies the intersection of chemistry and medicine but also represents a pathway towards innovative diagnostic and therapeutic techniques. As we explore the potential applications, we may uncover even more surprising benefits hidden within its molecular architecture.

Synonyms
iodamide
Uromiro
Urombrine
440-58-4
Ametriiodic acid
ametriodinic acid
Ametriiodinic acid
Iodamida
Uromiron
Iodamidum
Jodamidum
Jodomiron 380
Jodomiron
Iodamidum [INN-Latin]
SH 926
Iodamida [INN-Spanish]
3-acetamido-5-(acetamidomethyl)-2,4,6-triiodobenzoic acid
Iodamide [USAN]
Iodamide (radiopaque substance)
Iodamide [USAN:INN:BAN:JAN]
alpha,5-Diacetamido-2,4,6-triiodo-m-toluic acid
EINECS 207-125-1
Jodomiron (TN)
BRN 2175358
4RII332O0R
DTXSID1023150
CHEBI:31703
Benzoic acid, 3-(acetylamino)-5-((acetylamino)methyl)-2,4,6-triiodo-
IODAMIDE [INN]
IODAMIDE [JAN]
IODAMIDE [MI]
B-4130
SH-926
IODAMIDE [MART.]
IODAMIDE [WHO-DD]
3-Acetamido-5-acetamidomethyl-2,4,6-triiodobenzoic acid
DTXCID003150
3-Acetylaminomethyl-5-acetylamino-2,4,6-triiodobenzoic acid
3-(Acetylamino)-5-((acetylamino)methyl)-2,4,6-triiodobenzoic acid
NCGC00094851-01
Iodamidum (INN-Latin)
Iodamida (INN-Spanish)
3-(acetylamino)-5-[(acetylamino)methyl]-2,4,6-triiodobenzoic acid
IODAMIDE (MART.)
.ALPHA.,5-DIACETAMIDO-2,4,6-TRIIODO-M-TOLUIC ACID
Iodamide;Jodomiron 380; SH 926; Urombrine; Uromiro; Uromiron
CAS-440-58-4
UNII-4RII332O0R
B 4130
Spectrum_001074
Spectrum2_001070
Spectrum3_000613
Spectrum4_000798
Spectrum5_001597
SCHEMBL37885
BSPBio_002146
Iodamide (JAN/USAN/INN)
KBioGR_001276
KBioSS_001554
SPECTRUM1500772
SPBio_001060
CHEMBL1201239
KBio2_001554
KBio2_004122
KBio2_006690
KBio3_001646
V08AA03
VVDGWALACJEJKG-UHFFFAOYSA-N
HMS1921I04
HMS2092K10
Pharmakon1600-01500772
Tox21_111346
CCG-39027
NSC757423
AKOS040752085
Tox21_111346_1
DB08948
NCGC00094851-02
NCGC00094851-03
NCGC00094851-05
SBI-0051607.P002
NS00006057
D01376
AB00052175_02
SR-05000001565
m-Toluic acid, alpha-5-diacetamido-2,4,6-triiodo-
Q3801333
SR-05000001565-1
3-Acetylamino-5-acetylaminomethyl-2,4,6-triiodobenzoic acid
m-Toluic acid, alpha-5-diacetamido-2,4,6-triiodo-(7CI,8CI)
207-125-1