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Iohexol

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Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
3-acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic acid
State
State

At room temperature, Iohexol is mainly available as a contrast media in solution form, thus appearing as a clear, colorless to pale yellow liquid in clinical settings.

Melting point (Celsius)
173.50
Melting point (Kelvin)
446.70
Boiling point (Celsius)
431.80
Boiling point (Kelvin)
705.00
General information
Molecular weight
821.14g/mol
Molar mass
821.1400g/mol
Density
2.0113g/cm3
Appearence

Iohexol is generally a white to off-white crystalline powder. It is practically odorless and is known for its high aqueous solubility. It is commonly supplied in liquid form for use as a contrast medium.

Comment on solubility

Solubility of 3-acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic acid

The solubility of 3-acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic acid, a compound characterized by its complex structure, can be influenced by various factors. Understanding its solubility characteristics is crucial for applications in medicinal chemistry and other areas. Here are some key points to consider:

  • Polar vs. Non-Polar Nature: This compound contains multiple functional groups, such as amido and carboxylic acid groups, which can create polar interactions. Consequently, it may exhibit increased solubility in polar solvents like water or methanol.
  • Effect of Iodine Atoms: The presence of tri-iodinated groups can alter hydrophobic characteristics, making the compound less soluble in non-polar solvents due to larger iodine atoms disrupting the solvation process.
  • Temperature Dependence: As with many organic compounds, solubility can vary with temperature. It is essential to consider the solubility at different temperatures to understand its behavior in various environments.
  • pH Influence: The acidic nature of the benzoic acid group suggests that solubility may also be affected by the pH of the solution, enabling greater solubility in more basic conditions where deprotonation may occur.

In summary, the solubility of 3-acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic acid is a multifaceted topic that requires consideration of chemical structure, environmental conditions, and solvent interactions. By taking these factors into account, researchers can better predict and manipulate the solubility profile for various applications.

Interesting facts

Interesting Facts about 3-Acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic Acid

3-Acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic acid is a complex compound that belongs to the class of benzoic acids. Here are some noteworthy aspects of this intriguing substance:

  • Molecular Structure: This compound features a benzoic acid core that is heavily substituted with iodine atoms and amino groups. The trifunctional nature of its structure allows for varied interactions in biological systems.
  • Biological Relevance: Compounds like this one are often studied for their potential applications in medical imaging, particularly in relation to their iodine content, which is useful for enhancing contrast in X-ray and CT imaging.
  • Synthesis and Reactions: The synthesis of such compounds may involve multi-step organic reactions, including acylation and iodination processes, making it a valuable teaching example in organic chemistry courses.

Applications and Significance

The potential applications of 3-acetamido-5-(butanoylamino)-2,4,6-triiodo-benzoic acid extend beyond just its chemical structure:

  • Pharmaceutical Development: Its structural components may serve as a framework for the development of new therapeutic agents.
  • Research Tool: This compound is significant in biochemical research for studying the interactions of halogenated benzoic acids with biological substrates.

In the realm of chemical education, it's essential to recognize the importance of such compounds in fostering an understanding of organic synthesis, structure-activity relationships, and the broader implications in pharmaceuticals and diagnostics. As stated by scientists, "The true beauty of chemistry lies in the connections we make", and compounds like this showcase the intricate dance of atoms and the powerful stories they tell.

Synonyms
BRN 3007406
BENZOIC ACID, 3-ACETAMIDO-5-BUTYRAMIDO-2,4,6-TRIIODO-
19719-03-0
3-Acetamido-5-butyramido-2,4,6-triiodobenzoic acid
DTXSID20173386
DTXCID6095877