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Iodixanol

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Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
3-(acetamidomethyl)-5-[3-[2-[2-[2-[3-[3-(acetamidomethyl)-5-carboxy-2,4,6-triiodo-anilino]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2,4,6-triiodo-benzoic acid
State
State
At room temperature, iodixanol is typically a solid, but it is most commonly encountered in the form of a solution as it is used as a contrast agent in medical imaging.
Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1550.20g/mol
Molar mass
1 550.1980g/mol
Density
1.6200g/cm3
Appearence
Iodixanol is an amorphous solid, often appearing as a white to off-white powder. It may also be found in solutions when used for medical imaging purposes.
Comment on solubility

Solubility of 3-(acetamidomethyl)-5-[3-[2-[2-[2-[3-[3-(acetamidomethyl)-5-carboxy-2,4,6-triiodo-anilino]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2,4,6-triiodo-benzoic acid

The solubility of 3-(acetamidomethyl)-5-[3-[2-[2-[2-[3-[3-(acetamidomethyl)-5-carboxy-2,4,6-triiodo-anilino]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2,4,6-triiodo-benzoic acid can be quite complex due to its intricate molecular structure. Understanding its solubility behavior is essential for potential applications and formulations.

Key Factors Affecting Solubility:

  • Molecular Interactions: The presence of acetamido and carboxy functional groups suggests the potential for hydrogen bonding, which may enhance solubility in polar solvents.
  • Iodine Substitution: The triiodo substitution may influence solubility, as halogens can affect polarity and molecular interactions with solvents.
  • Chain Length: The lengthy ethoxy chains may introduce hydrophobic character, potentially decreasing solubility in water but increasing in organic solvents.

In general, compounds with a large number of functional groups often have increased solubility in polar solvents due to the ability to form favorable interactions. However, the balance between hydrophilic and hydrophobic regions within the molecule complicates this prediction. Therefore, it is recommended to conduct solubility tests in various media to delineate the effective solubility profile.


As a rule of thumb, it is often said, "like dissolves like." Hence, this compound may show better solubility in polar solvents like water or dimethyl sulfoxide, while being less soluble in less polar solvents. An empirical approach to determining solubility will yield the most reliable insights into this compound’s behavior in different environments.

Interesting facts

Interesting Facts about 3-(Acetamidomethyl)-5-[3-[2-[2-[2-[3-[3-(Acetamidomethyl)-5-carboxy-2,4,6-triiodo-anilino]-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2,4,6-triiodo-benzoic Acid

This compound, known for its complex structure and rich chemistry, showcases the intricate relationships among heterocycles, functional groups, and iodine incorporation. Here are some fascinating aspects:

  • Unique Structural Features: The compound contains multiple functional groups including acetamido and carboxylic acid moieties, which suggest potential biological activity and fascinating interactions in biochemical pathways.
  • Triiodo Component: The presence of triiodo groups in the structure implies that the compound may exhibit unique radiological properties. Compounds with iodine are often investigated for their use in medical imaging techniques, such as MRI and CT scans.
  • Potential Pharmaceutical Applications: Due to the structural complexity, this compound may serve as a precursor or lead compound in the development of pharmaceuticals, particularly in cancer therapy, given its potential to target specific pathways.
  • Multifunctionality: The integration of 2,4,6-triiodo and propoxy side chains allows for multifunctionality, which may enhance the compound's solubility or binding affinity in biological systems, making it a point of interest for medicinal chemists.
  • Research Importance: Scientists are increasingly focused on designing compounds that have specific targeting capabilities. This compound's intricate design might help uncover new avenues in drug discovery.

With its rich composition and potential applications in medicine and imaging technology, this compound embodies the beauty and complexity of modern chemistry. Continuous research into its properties might unlock secrets that could lead to ground-breaking innovations in drug development.

Synonyms
BRN 2800923
Benzoic acid, 3,3'-(ethylenebis(oxyethyleneoxyethylenecarbonylimino))bis(5-(acetamidomethyl)-2,4,6-triiodo-
25901-41-1
DTXSID70180560
RefChem:326951
DTXCID10103051