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Cefotaxime

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Identification
Molecular formula
C16H17N5O7S2
CAS number
63527-52-6
IUPAC name
3-(acetoxymethyl)-7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, cefotaxime is solid, typically produced and stored as a powder.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
477.51g/mol
Molar mass
477.5050g/mol
Density
1.7100g/cm3
Appearence

Cefotaxime is a white to light yellow crystalline powder that is odorless or has a faint odor. It is soluble in water and sparingly soluble in methanol. When prepared in injectable forms, it usually appears as a clear, colorless solution.

Comment on solubility

Solubility of 3-(acetoxymethyl)-7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of the compound C16H17N5O7S2 is an important aspect, particularly given its complex structure which implies variability in solubility across different solvents.

In general, several factors affect the solubility of this compound:

  • Polarity: The presence of multiple functional groups, such as the amino and carboxylate, suggest a degree of polarity, which could enhance solubility in polar solvents like water.
  • Hydrophobic Regions: The bicyclic structure may introduce hydrophobic characteristics, potentially limiting solubility in aqueous environments.
  • Interactions: The interaction between solute and solvent plays a crucial role; solubility could improve in solvents capable of hydrogen bonding.

Typically, compounds of this nature are more soluble in organic solvents compared to water. For instance, dimethyl sulfoxide (DMSO) or ethanol may serve as suitable solvents for dissolution. Conversely, in water, solubility may be less favored due to the compound's structural complexity.

As a result, experimental solubility tests are essential to determine the precise solubility behavior of this compound under varied conditions, and it is key to note that solubility can significantly influence its bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about 3-(Acetoxymethyl)-7-[[2-(2-Aminothiazol-4-yl)-2-Methoxyimino-Acetyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate

This complex compound belongs to a fascinating class of molecules known for their biological activity. Often, compounds with such intricate designs are explored for their potential in pharmaceuticals, particularly in the development of antibiotics and anti-cancer agents.

Key Highlights

  • Structural Diversity: The structure of this compound features unique bicyclic frameworks, which contribute to its potentially enhanced biological properties.
  • Biological Relevance: Molecules containing thiazoles and oxo groups are often associated with improved activity against various pathogens. The presence of amino groups can also enhance their interaction with biological targets.
  • Synthetic Pathways: The synthesis of such compounds is a great example of how organic chemistry can create complex molecules. Chemists often utilize various reaction conditions and reagents to construct these intricate structures.

As scientists continue to explore such compounds, they not only provide insight into fundamental chemistry principles but also pave the way for new medications and treatments. In the words of Dr. Marie Curie, "Nothing in life is to be feared, it is only to be understood." Understanding compounds like this can lead to groundbreaking advancements in therapeutic applications.

Overall, the study of 3-(acetoxymethyl)-7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate illustrates the impact of structural complexity on biological efficacy, showcasing a pivotal avenue in drug discovery.