Cefotaxime | Solubility of Things

Identification

Molecular formula

C₁₆H₁₇N₅O₇S₂

CAS number

63527-52-6

IUPAC name

3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

State

At room temperature, cefotaxime is typically in a solid state, usually found as a powder intended for reconstitution or blending into suitable pharmaceutical formulations.

Melting point (Celsius)

160.00

Melting point (Kelvin)

433.00

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

455.44g/mol

Molar mass

455.4430g/mol

Density

1.6200g/cm³

Appearence

Cefotaxime typically appears as a white to slightly yellow crystalline powder. It is often provided in a lyophilized (freeze-dried) form for pharmaceutical applications.

Comment on solubility

Solubility of 3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

The solubility of 3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid in various solvents can be influenced by its unique chemical structure, which contains multiple functional groups. Understanding its solubility helps in predicting its behavior in different environments, which is crucial for applications in pharmaceutical and biochemical fields.

Solubility Characteristics

Water Solubility: Given the presence of polar functional groups such as carboxylic acid and acetoxymethyl, the compound is likely to exhibit some degree of solubility in water, particularly at lower pH levels.
Organic Solvent Solubility: This compound may find enhanced solubility in organic solvents such as DMSO or methanol due to hydrophobic interactions associated with the aromatic and thiazolidine ring structures.
pH Dependence: The solubility may vary significantly with changes in pH, particularly because of the acidic carboxyl group that can ionize, thus increasing water solubility under alkaline conditions.

In summary, estimating the solubility of 3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid requires consideration of solvent interactions and environmental conditions. Understanding these factors is essential for applications in drug formulation and delivery.

Interesting facts

Interesting Facts about 3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

This fascinating compound belongs to a class of chemicals that demonstrates both structural complexity and biological significance. Here are some captivating aspects:

Structural Diversity: The compound features a unique bicyclic structure which includes a thia (sulfur-containing) ring, enhancing its reactivity and potential interactions with biological systems.
Pharmaceutical Relevance: Compounds with similar structures are often investigated for their bioactivity, including antibacterial and antifungal properties, making them potential candidates for new medications.
Synthetic Challenges: Due to its intricate structure, synthesizing this compound requires advanced organic chemistry techniques, often incorporating protective groups and multi-step reactions.
Mechanism of Action: Understanding how such compounds interact at the molecular level can offer insights into enzymatic pathways or receptor interactions that are essential for drug development.
Research Potential: The chemical shows promise as a lead compound for designing derivatives that could enhance specific biological activities or reduce side effects.

As a student of chemistry, it's critical to appreciate not only the structural characteristics of compounds like this one but also their broader implications in the field of medicinal chemistry. As a quote from Robert H. Grubbs states, "The study of chemistry can be a gateway to innovation." By dissecting the complexities of such compounds, we can pave the way for advancements in therapeutic applications.