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3-Acetylbenzenesulfonyl fluoride

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Identification
Molecular formula
C8H7FO3S
CAS number
2443-60-3
IUPAC name
3-acetylbenzenesulfonyl fluoride
State
State

At room temperature, 3-acetylbenzenesulfonyl fluoride is a solid. It retains its crystalline structure unless subjected to temperatures near its melting point.

Melting point (Celsius)
47.00
Melting point (Kelvin)
320.15
Boiling point (Celsius)
332.82
Boiling point (Kelvin)
605.97
General information
Molecular weight
218.22g/mol
Molar mass
218.2180g/mol
Density
1.3633g/cm3
Appearence

3-Acetylbenzenesulfonyl fluoride typically appears as a white or off-white crystalline solid. The precise texture and coloration can depend on the specific conditions and the purity of the compound, but it is generally not colorful.

Comment on solubility

Solubility of 3-acetylbenzenesulfonyl fluoride

3-acetylbenzenesulfonyl fluoride is a compound that exhibits unique solubility characteristics, influencing its applications in various fields.

  • Solvent Compatibility: This compound readily dissolves in organic solvents, such as:
    • Dimethyl sulfoxide (DMSO)
    • Acetone
    • Ethanol
  • Water Solubility: It has low solubility in water, which can limit its use in aqueous environments.

In the chemical context, solubility is a critical property that can dictate the reactivity and interaction of compounds. As such, it is essential to consider the intended application when assessing the solubility of 3-acetylbenzenesulfonyl fluoride. As quoted from a solubility study, "The solubility profile is a vital component in the design and application of sulfonyl fluoride compounds."

To summarize:

  1. High solubility in organic solvents
  2. Low solubility in water

This duality in solubility patterns makes 3-acetylbenzenesulfonyl fluoride an intriguing subject for researchers and practitioners in the field of organic chemistry.

Interesting facts

Interesting Facts about 3-Acetylbenzenesulfonyl Fluoride

3-Acetylbenzenesulfonyl fluoride is a fascinating compound within the realm of organic chemistry. Often utilized in the synthesis of various organic molecules, this compound is notable for its unique structure and reactivity. Here are some compelling facts about 3-acetylbenzenesulfonyl fluoride:

  • Nucleophilic reactions: The sulfonyl fluoride functional group makes this compound highly reactive towards nucleophiles, allowing for efficient transformations and synthesis of target molecules.
  • Precursor to sulfonamides: It plays a significant role as a precursor in the synthesis of sulfonamide pharmaceuticals, which are crucial in medicinal chemistry for their antibacterial properties.
  • Pharmaceutical relevance: The compound is often investigated in drug design and development due to its ability to modify biological targets, enhancing the activity of various drugs.

Research Insights

Recent studies indicate that compounds similar to 3-acetylbenzenesulfonyl fluoride can exhibit selective inhibitory effects against certain enzymes, making them potential candidates for further pharmacological exploration. As noted by researchers, “the application of sulfonyl compounds in drug development is an exciting area, given their effectiveness and versatility.”

The development and utilization of 3-acetylbenzenesulfonyl fluoride in synthetic processes highlight its importance in both academic research and practical applications. Its chemistry continues to inspire novel approaches in organic synthesis and medicinal chemistry.

Synonyms
3-Acetylbenzenesulfonyl fluoride
709-60-4
Acetylbenzenesulfonyl fluoride
m-Acetyl benzene sulfonyl fluoride
EINECS 211-912-5
NSC 87557
BRN 2721786
NEVFJPDNDDMQGD-UHFFFAOYSA-
DTXSID70221129
ACBZSFFL
DTXCID20143620
inchi=1/c8h7fo3s/c1-6(10)7-3-2-4-8(5-7)13(9,11)12/h2-5h,1h3
nevfjpdnddmqgd-uhfffaoysa-n
m-(Fluorosulfonyl)acetophenone
Benzenesulfonylfluoride, 3-acetyl-
Benzenesulfonyl fluoride, 3-acetyl-
3-acetylbenzene-1-sulfonyl fluoride
BENZENESULFONYL FLUORIDE, m-ACETYL-
3-Acetylbenzenesulphonyl fluoride
ZP99KN4EB6
NSC-87557
starbld0000260
UNII-ZP99KN4EB6
m-Acetylbenzenesulfonylfluoride
m-(Fluorosulphonyl)acetophenone
SCHEMBL4093243
3-ace-tylbenzenesulfonyl fluoride
NSC87557
Benzenesulphonyl fluoride, m-acetyl-
Benzenesulphonyl fluoride, 3-acetyl-
AKOS030573810
3-ACETYLBENZENE SULFONYL FLUORIDE
CS-0240076
NS00042022
EN300-224333
Z1269121200