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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
State
State

Noscapine is a solid at room temperature. It exists in the form of crystalline powder and is stable under standard conditions.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
277.50
Boiling point (Kelvin)
550.65
General information
Molecular weight
413.45g/mol
Molar mass
413.4520g/mol
Density
1.3038g/cm3
Appearence

Noscapine typically appears as a white crystalline solid. It is often odorless and has a bitter taste. This compound is commonly available in powder form for use in its therapeutic applications.

Comment on solubility

Solubility of 3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The compound 3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, represented by the chemical formula C22H23NO7, exhibits unique solubility characteristics that can be attributed to its complex molecular structure. Understanding its solubility is crucial for various applications, especially in pharmacology and organic synthesis.

Factors Influencing Solubility

The solubility of this compound can be affected by numerous factors:

  • Molecular Structure: The presence of multiple hydroxyl (-OH) groups often enhances solubility in polar solvents like water.
  • Polarity: Given the overall structure, the molecule may possess a mix of polar and non-polar characteristics, impacting its solubility profile.
  • Solvent Choice: It is likely to be more soluble in organic solvents such as ethanol or acetone compared to water.
  • Temperature: Increased temperatures typically improve solubility for many organic compounds, although specific tests would be needed for this one.

Expected Solubility Behavior

Based on the analysis, we can make the following predictions:

  • This compound is likely to have low to moderate solubility in cold water due to its large hydrophobic structure.
  • It may show higher levels of solubility in alcohols or other polar organic solvents.
  • Its complex structure could also lead to potential hydrogen bonding with solvents, influencing its solubility properties.

In summary, while the precise solubility of 3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one can vary, it is essential to conduct empirical tests to fully understand its solubility in various conditions and solvents.

Interesting facts

Interesting Facts about 3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

This complex compound, known as a member of the isoquinoline family, exhibits fascinating structural and chemical properties that make it a subject of study in various fields, particularly in medicinal chemistry.

Natural Sources and Synthesis

Isolated from certain plant species, this compound is of significant interest for several reasons:

  • Phytochemical Significance: It is often studied for its potential biological activities, including antioxidant and anti-inflammatory properties.
  • Synthetic Versatility: The unique structure allows for diverse synthetic pathways, inviting exploration of both natural and synthetic methodologies in drug development.

Biological Activities

Research has indicated that compounds similar to this structure may exhibit:

  • Antitumor Activity: Preliminary studies suggest potential effects against certain cancer cell lines.
  • Neuroprotective Properties: Some isoquinoline derivatives have shown promise in protecting neuronal cells under stress conditions.

Structural Features

The intricate structure of this compound can be appreciated through its:

  • Allyl Group: This component contributes to the compound's reactivity and could be pivotal in its interaction with biological targets.
  • Hydroxy Groups: The presence of hydroxyl functional groups often enhances solubility and may facilitate hydrogen bonding, impacting its biological activity.

In the words of a famous chemist, "It is through the exploration of complex structures that we unveil the mysteries of nature's pharmacy." This compound serves as an excellent reminder of the rich potential that lies within organic molecules and their applications in health and medicine.

As research continues, the possibilities surrounding 3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one are only just beginning to unfold. Keeping a keen eye on ongoing studies will reveal more about its efficacy and applications in the future.

Synonyms
4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Naloxone(-)
Nalone (Salt/Mix)
Narcan (Salt/Mix)
Normorphinone, N-allyl-dihydro-14-hydroxy-
Oprea1_030545
CHEMBL609673
SCHEMBL10031249
BDBM86260
CHEBI:91663
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5.alpha.)-
UZHSEJADLWPNLE-UHFFFAOYSA-N
NSC_10064
CAS_465-65-6
L000674
BRD-A37541666-003-01-6
Q27163485
17-Allyl-4,5-.alpha.-epoxy-3,14-dihydroxymorphinan-6-one
Morphinan-6-one, 17-allyl-4,5.alpha.-epoxy-3,14-dihydroxy-
Morphinan-6-one, 4,5.alpha.-epoxy-3,14-dihydroxy-17-(2-propenyl)-
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5.alpha.)-
12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furan-5-one
4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
4aH-8,9c-Iminoethanophenanthro(4,5-bcd)furan-5(6H)-one, N-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-