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Histidine

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Identification
Molecular formula
C6H9N3O2
CAS number
71-00-1
IUPAC name
3-amino-2-hydroxy-2-(1H-imidazol-5-ylmethyl)-5-methyl-hexanoic acid
State
State

Histidine is a solid at room temperature. It is stable under normal conditions but can decompose when exposed to light and moisture over extended periods.

Melting point (Celsius)
282.00
Melting point (Kelvin)
555.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
155.15g/mol
Molar mass
209.2660g/mol
Density
1.4100g/cm3
Appearence

Histidine appears as a white crystalline powder. It is odorless and has a bitter taste. Being a crystalline compound, it often forms small granules that are clear under magnification.

Comment on solubility

Solubility of 3-amino-2-hydroxy-2-(1H-imidazol-5-ylmethyl)-5-methyl-hexanoic acid

The compound 3-amino-2-hydroxy-2-(1H-imidazol-5-ylmethyl)-5-methyl-hexanoic acid, with the chemical formula C6H9N3O2, displays interesting solubility characteristics that reflect its complex structure.

Factors Influencing Solubility

  • Polarity: Due to the presence of multiple functional groups, including an amino and a hydroxyl group, the compound is expected to have a high degree of polarity, enhancing its capacity to dissolve in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl group allows for hydrogen bonding with water molecules, contributing to increased solubility.
  • Molecular Interactions: The imidazole moiety may facilitate interactions with other groups, possibly influencing solubility in various solvent systems.

Given these factors, it can be inferred that:

  • This compound is likely to be soluble in water due to its polar characteristics and ability to form hydrogen bonds.
  • However, solubility may diminish in non-polar solvents, reflecting typical behavior for amino acids and derivatives.

Thus, understanding the solubility behavior of this compound is crucial for its potential applications in pharmaceuticals and biochemistry.

Interesting facts

Interesting Facts about 3-amino-2-hydroxy-2-(1H-imidazol-5-ylmethyl)-5-methyl-hexanoic acid

This compound, often referred to in scientific literature due to its unique structure and properties, is an intriguing member of the amino acid family. Its IUPAC name presents a complex yet fascinating chemical structure, characterized by the presence of an imidazole group, which is significant in biochemistry.

Biochemical Significance

Here are some key aspects of this compound:

  • Amino Acid Derivative: This compound serves as a derivative of a typical amino acid, showcasing amino functionality, which is essential for protein synthesis.
  • Imidazole Group: The imidazole ring is known for its role in enzyme catalysis, providing a site for proton transfer and electron resonance; it's also a crucial component in histidine, an important amino acid in many biological systems.
  • Hydroxyl Functionality: The hydroxyl (-OH) group contributes to the compound's solubility and potential reactivity, indicating its possible roles in metabolic processes.

Potential Applications

This compound's structural features suggest various applications:

  • Pharmaceutical Development: Given its unique structure, there is interest in exploring its potential as a pharmaceutical agent, especially in disorders related to amino acid metabolism.
  • Biochemical Research: Researchers are keen on investigating its interactions within biological systems, particularly how it may influence enzyme activity or signal transduction pathways.

Conclusion

In conclusion, 3-amino-2-hydroxy-2-(1H-imidazol-5-ylmethyl)-5-methyl-hexanoic acid is not just another compound; it represents the intricate connections between biochemistry, structural biology, and potential therapeutic contexts. As we continue to unravel its secrets, it may very well lead to groundbreaking discoveries in science and medicine.

Synonyms
((2R,3S)-3-Amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methyl)-5-methylhexanoic Acid
ILH-4249-V