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3-Amino-2-methyl-5-nitrobenzamide

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Identification
Molecular formula
C8H9N3O3
CAS number
107879-81-6
IUPAC name
3-amino-2-methyl-5-nitro-benzamide
State
State

At room temperature, 3-Amino-2-methyl-5-nitrobenzamide is typically a solid. It is stable under standard conditions and does not evaporate nor dissolve easily in water, given its crystalline structure.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
345.00
Boiling point (Kelvin)
618.15
General information
Molecular weight
195.18g/mol
Molar mass
195.1840g/mol
Density
1.3440g/cm3
Appearence

The compound appears as a crystalline solid, typically a pale yellow in color due to the presence of the nitro group. The crystals are usually fine and may appear powdery when ground. If closely examined, they can form intricate crystalline structures.

Comment on solubility

Solubility of 3-amino-2-methyl-5-nitro-benzamide

3-amino-2-methyl-5-nitro-benzamide, a compound featuring both amino and nitro functional groups, presents a unique profile when it comes to solubility. Its solubility characteristics can be influenced by several factors, which include:

  • Polarity: The presence of the amino group contributes significantly to the overall polarity of the molecule, making it more likely to dissolve in polar solvents such as water.
  • Hydrogen Bonding: The NH2 group is capable of forming hydrogen bonds with water molecules, enhancing solubility. Conversely, the nitro group may also engage in interactions that affect solubility policies.
  • Temperature: Generally, an increase in temperature can improve the solubility of many organic compounds, including substituted benzamides. Therefore, heating might facilitate the dissolution process.
  • Solvent Compatibility: While it is soluble in polar solvents, it may show limited solubility in non-polar solvents. Compatibility with solvents should be carefully evaluated depending on the intended application.

Overall, one might say, "The presence of functional groups shapes the interactive nature of solubility." In practice, this means that 3-amino-2-methyl-5-nitro-benzamide is likely to be moderately soluble in water but may require specific conditions to optimize its solubility for various applications.

Interesting facts

Interesting Facts about 3-Amino-2-methyl-5-nitro-benzamide

3-Amino-2-methyl-5-nitro-benzamide is a fascinating organic compound that finds significance in various fields, particularly in medicinal chemistry and organic synthesis. Here are some interesting aspects of this compound:

  • Functional Groups: This compound features several important functional groups, including an amino group, a nitro group, and a benzamide moiety. Each of these groups contributes to the compound's reactivity and potential applications in drug development.
  • Synthesis Potential: Due to its unique structural features, 3-amino-2-methyl-5-nitro-benzamide can serve as a key intermediate in the synthesis of more complex molecules. The presence of both amino and nitro groups can enable chemists to perform various reactions, such as nucleophilic substitutions and coupling reactions.
  • Drug Development: Compounds with amino and nitro substituents are often explored for their biological activity. Research indicates that similar compounds may exhibit antibacterial and anti-inflammatory properties, making them worthy of evaluation in drug testing.
  • Analytical Techniques: The characterization of 3-amino-2-methyl-5-nitro-benzamide often involves advanced analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. These methods are critical for confirming the structure and purity of the compound in laboratory settings.
  • Environmental Considerations: As with many nitro compounds, there are concerns regarding their environmental impact and toxicity. Understanding the degradation pathways of such compounds is essential for assessing their ecological footprints.

In conclusion, 3-amino-2-methyl-5-nitro-benzamide stands as a compound of both scientific curiosity and potential utility, inviting further studies that could lead to valuable discoveries in both chemistry and pharmacology.

Synonyms
3-Amino-2-methyl-5-nitrobenzamide
3572-44-9
3-Amino-5-nitro-o-toluamide
Benzamide, 3-amino-2-methyl-5-nitro-
KA9YLT68HA
Benzamide, 3-amino-2-methyl-5-nitro-(9CI)
684-517-2
Anot
3-ANOT
2-Methyl-3-amino-5-nitrobenzamide
o-TOLUAMIDE, 3-AMINO-5-NITRO-
UNII-KA9YLT68HA
BRN 2114950
ANOT [MI]
3-Amino-5-nitro-o-toluamid
SCHEMBL377142
CHEMBL510184
DTXSID00189243
3572-44-9 (non-salt)
RBLRQBGOUCRKRT-UHFFFAOYSA-N
AKOS040758079
HY-136458
CS-0129634
NS00040585
3-Amino-2-methyl-5-nitrobenzamide hydrochloride
Q27282148
3-Amino-2-methyl-5-nitrobenzamide, VETRANAL(TM), analytical standard