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Melphalan

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Identification
Molecular formula
C13H18Cl2N2O2
CAS number
148-82-3
IUPAC name
3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
State
State
Melphalan is a solid at room temperature, typically appearing as a crystalline powder.
Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
305.20g/mol
Molar mass
305.1920g/mol
Density
1.3200g/cm3
Appearence

Melphalan appears as a white to off-white crystalline powder. It is essentially odorless.

Comment on solubility

Solubility of 3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

The solubility of 3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid is an intriguing aspect that can influence its applications and effectiveness in various environments. Here are some key points regarding its solubility:

  • Polarity Considerations: Given the presence of amine and carboxylic acid functional groups, the compound is likely to exhibit moderate polarity. This can enhance its solubility in polar solvents like water.
  • Potential Solvents: It's anticipated to be soluble in aqueous environments due to hydrogen bonding capabilities, while showing limited solubility in non-polar solvents.
  • pH Dependency: The solubility might vary significantly with pH alterations. At lower pH levels, the carboxylic group could become protonated, affecting overall solubility.
  • Temperature Factors: Increased temperature can generally lead to enhanced solubility for many organic compounds; thus, the solubility of this compound may increase with rising temperatures.

In summary, the solubility of 3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid is influenced by various factors, and its practical implications must be carefully considered in related applications.

Interesting facts

Interesting Facts about 3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid is a fascinating compound with notable significance in medicinal chemistry and pharmacology. This compound is particularly recognized for its role in therapeutics, particularly in the treatment of various forms of cancer. Here are some intriguing aspects:

  • Structure and Function: The presence of the bis(2-chloroethyl)amino group indicates that this compound belongs to a class of compounds known as alkylating agents. These agents are known to initiate cross-linking of DNA, thereby inhibiting cancer cell division.
  • Mechanism of Action: With its unique structural components, this compound functions by adding alkyl groups to the DNA molecule, which can lead to apoptosis (programmed cell death) in rapidly dividing cancer cells. It showcases the intelligent design of chemotherapeutic agents that target malignancies selectively.
  • Therapeutic Potential: The derivative of amino acids offers promising therapeutic applications, particularly due to its ability to disrupt cellular proliferation in tumors. This opens doors for further exploration in drug design to enhance targeting and minimize side effects.
  • Safety Profile: As with many alkylating agents, there is a balance to maintain between efficacy and toxicity. Research is ongoing into how to better manage adverse effects while maximizing therapeutic potential.
  • Research Impact: This compound exemplifies the intersection of organic chemistry and biochemistry, where understanding molecular structure can lead to significant breakthroughs in cancer therapies.

In summary, 3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid remains a subject of keen interest in the scientific community. As researchers delve deeper into its properties, the hope is to unlock further therapeutic possibilities that could revolutionize cancer treatment.

Synonyms
1952-98-3
Ho-14
BRN 2750748
p-Bis(2-chloroethyl)amino-beta-phenylalanine
3-(p-(Bis(2-chloroethyl)amino)phenyl)-beta-alanine
beta-ALANINE, 3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-
4-14-00-01686 (Beilstein Handbook Reference)
Hydrocinnamic acid, beta-amino-p-(bis(2-chloroethyl)amino)-
Hydrocinnamic acid, beta-amino-p-(bis(2-chloroethyl)amino)-(8CI)
3-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
beta-Amino-4-[bis(2-chloroethyl)amino]benzenepropanoic acid
3-AMINO-3-{4-[BIS(2-CHLOROETHYL)AMINO]PHENYL}PROPANOIC ACID
SCHEMBL13499788
DTXSID80941285